BAIT
PROS1
PROS, PS21, PS22, PS23, PS24, PS25, PSA, THPH5, THPH6
protein S (alpha)
GO Process (11)
GO Function (1)
GO Component (8)
Gene Ontology Biological Process
- blood coagulation [TAS]
- cellular protein metabolic process [TAS]
- innate immune response [TAS]
- leukocyte migration [TAS]
- negative regulation of endopeptidase activity [TAS]
- peptidyl-glutamic acid carboxylation [TAS]
- platelet activation [TAS]
- platelet degranulation [TAS]
- post-translational protein modification [TAS]
- proteolysis [TAS]
- regulation of complement activation [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
TBK1
NAK, T2K
TANK-binding kinase 1
GO Process (17)
GO Function (4)
GO Component (3)
Gene Ontology Biological Process
- I-kappaB kinase/NF-kappaB signaling [TAS]
- MyD88-independent toll-like receptor signaling pathway [TAS]
- TRIF-dependent toll-like receptor signaling pathway [TAS]
- inflammatory response [TAS]
- innate immune response [TAS]
- negative regulation of type I interferon production [TAS]
- positive regulation of I-kappaB kinase/NF-kappaB signaling [IEP]
- positive regulation of interferon-alpha production [IDA]
- positive regulation of interferon-beta production [IDA]
- positive regulation of peptidyl-serine phosphorylation [NAS]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- positive regulation of type I interferon production [TAS]
- response to virus [TAS]
- toll-like receptor 3 signaling pathway [TAS]
- toll-like receptor 4 signaling pathway [TAS]
- toll-like receptor signaling pathway [TAS]
- type I interferon production [TAS]
Gene Ontology Molecular Function
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Toward an understanding of the protein interaction network of the human liver.
Proteome-scale protein interaction maps are available for many organisms, ranging from bacteria, yeast, worms and flies to humans. These maps provide substantial new insights into systems biology, disease research and drug discovery. However, only a small fraction of the total number of human protein-protein interactions has been identified. In this study, we map the interactions of an unbiased selection of ... [more]
Mol. Syst. Biol. Oct. 13, 2011; 7(0);536 [Pubmed: 21988832]
Throughput
- High Throughput
Curated By
- BioGRID