BAIT
CRZ1
HAL8, TCN1, DNA-binding transcription factor CRZ1, L000004202, YNL027W
Transcription factor, activates transcription of stress response genes; nuclear localization is positively regulated by calcineurin-mediated dephosphorylation; rapidly localizes to the nucleus under blue light stress; can be activated in stochastic pulses of nuclear localization in response to calcium
GO Process (12)
GO Function (3)
GO Component (2)
Gene Ontology Biological Process
- cell wall chitin biosynthetic process [IGI]
- cellular response to blue light [IDA]
- ion homeostasis [IGI, IMP]
- positive regulation of cellular response to drug [IMP]
- positive regulation of sodium ion transport by positive regulation of transcription from RNA polymerase II promoter [IDA]
- positive regulation of transcription from RNA polymerase II promoter [IGI, IMP]
- positive regulation of transcription from RNA polymerase II promoter by calcium-mediated signaling [IGI, IMP]
- positive regulation of transcription from RNA polymerase II promoter by pheromones [IMP]
- positive regulation of transcription from RNA polymerase II promoter in response to alkaline pH [IMP]
- positive regulation of transcription from RNA polymerase II promoter in response to calcium ion [IMP]
- positive regulation of transcription from RNA polymerase II promoter in response to increased salt [IMP]
- regulation of potassium ion concentration by positive regulation of transcription from RNA polymerase II promoter [IDA, IGI, IMP]
Gene Ontology Molecular Function
Saccharomyces cerevisiae (S288c)
PREY
SRO7
SNI1, SOP1, L000003105, L000004193, YPR032W
Effector of Rab GTPase Sec4p; forms a complex with Sec4p and t-SNARE Sec9p; involved in exocytosis and docking and fusion of post-Golgi vesicles with plasma membrane; regulates cell proliferation and colony development via the Rho1-Tor1 pathway; homolog of Drosophila lgl tumor suppressor; SRO7 has a paralog, SRO77, that arose from the whole genome duplication
GO Process (4)
GO Function (2)
GO Component (3)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Saccharomyces cerevisiae (S288c)
Negative Genetic
Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores.
Publication
A Lipid E-MAP Identifies Ubx2 as a Critical Regulator of Lipid Saturation and Lipid Bilayer Stress.
Biological membranes are complex, and the mechanisms underlying their homeostasis are incompletely understood. Here, we present a quantitative genetic interaction map (E-MAP) focused on various aspects of lipid biology, including lipid metabolism, sorting, and trafficking. This E-MAP contains ∼250,000 negative and positive genetic interaction scores and identifies a molecular crosstalk of protein quality control pathways with lipid bilayer homeostasis. Ubx2p, ... [more]
Mol. Cell Aug. 22, 2013; 51(4);519-30 [Pubmed: 23891562]
Quantitative Score
- -5.092814 [S score]
Throughput
- High Throughput
Ontology Terms
- colony size (APO:0000063)
Additional Notes
- An Epistatic MiniArray Profile (E-MAP) analysis was used to quantitatively score genetic interactions based on fitness defects estimated from the colony size of double versus single mutants. Genetic interactions were considered significant if they had an S score > 2.5 for positive interactions (suppression) and S score < -2.5 for negative interactions (synthetic sick/lethality).
Curated By
- BioGRID