NRP1
Gene Ontology Biological Process
- VEGF-activated neuropilin signaling pathway [ISS]
- angiogenesis [IMP, ISS]
- angiogenesis involved in coronary vascular morphogenesis [ISS]
- artery morphogenesis [ISS]
- axon extension involved in axon guidance [ISS]
- axon guidance [NAS, TAS]
- axonogenesis involved in innervation [ISS]
- cell migration involved in sprouting angiogenesis [ISS]
- cell-cell signaling [TAS]
- cellular response to hepatocyte growth factor stimulus [IMP]
- cellular response to vascular endothelial growth factor stimulus [ISS]
- commissural neuron axon guidance [ISS]
- endothelial cell chemotaxis [IMP]
- endothelial tip cell fate specification [ISS]
- hepatocyte growth factor receptor signaling pathway [IMP]
- nerve development [ISS]
- neural crest cell migration involved in autonomic nervous system development [ISS]
- neuron migration [ISS]
- organ morphogenesis [TAS]
- patterning of blood vessels [ISS]
- platelet-derived growth factor receptor signaling pathway [IMP]
- positive chemotaxis [ISS]
- positive regulation of ERK1 and ERK2 cascade [ISS]
- positive regulation of axon extension involved in axon guidance [ISS]
- positive regulation of cytokine activity [TAS]
- positive regulation of endothelial cell migration [TAS]
- positive regulation of endothelial cell proliferation [TAS]
- positive regulation of peptidyl-tyrosine phosphorylation [IMP]
- positive regulation of retinal ganglion cell axon guidance [ISS]
- positive regulation of smooth muscle cell migration [TAS]
- protein localization to early endosome [ISS]
- regulation of retinal ganglion cell axon guidance [ISS]
- regulation of vesicle-mediated transport [TAS]
- retina vasculature morphogenesis in camera-type eye [ISS]
- retinal ganglion cell axon guidance [ISS]
- semaphorin-plexin signaling pathway [NAS]
- semaphorin-plexin signaling pathway involved in neuron projection guidance [ISS]
- signal transduction [TAS]
- sprouting angiogenesis [ISS]
- sympathetic ganglion development [ISS]
- sympathetic neuron projection extension [ISS]
- sympathetic neuron projection guidance [ISS]
- vascular endothelial growth factor receptor signaling pathway [IMP, TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
TGFBR3
Gene Ontology Biological Process
- BMP signaling pathway [IDA]
- cardiac epithelial to mesenchymal transition [IDA]
- cardiac muscle cell proliferation [ISS]
- cell growth [ISS]
- cell migration [ISS]
- definitive erythrocyte differentiation [ISS]
- definitive hemopoiesis [ISS]
- epithelial to mesenchymal transition [IDA]
- heart morphogenesis [ISS]
- heart trabecula formation [ISS]
- immune response [IMP]
- intracellular signal transduction [IMP]
- liver development [ISS]
- negative regulation of cellular component movement [IDA]
- negative regulation of epithelial cell proliferation [ISS]
- palate development [ISS]
- pathway-restricted SMAD protein phosphorylation [IMP]
- response to follicle-stimulating hormone [IDA]
- response to luteinizing hormone [IDA]
- response to prostaglandin E [IDA]
- transforming growth factor beta receptor signaling pathway [IDA, IMP]
- ventricular cardiac muscle tissue morphogenesis [ISS]
Gene Ontology Molecular Function- PDZ domain binding [ISS]
- SMAD binding [IMP]
- coreceptor activity [IDA]
- glycosaminoglycan binding [ISS, TAS]
- heparin binding [ISS]
- protein binding [IPI]
- transforming growth factor beta binding [IDA]
- transforming growth factor beta receptor activity, type III [IDA]
- transforming growth factor beta receptor binding [ISS]
- transforming growth factor beta-activated receptor activity [IDA]
- type II transforming growth factor beta receptor binding [IDA]
- PDZ domain binding [ISS]
- SMAD binding [IMP]
- coreceptor activity [IDA]
- glycosaminoglycan binding [ISS, TAS]
- heparin binding [ISS]
- protein binding [IPI]
- transforming growth factor beta binding [IDA]
- transforming growth factor beta receptor activity, type III [IDA]
- transforming growth factor beta receptor binding [ISS]
- transforming growth factor beta-activated receptor activity [IDA]
- type II transforming growth factor beta receptor binding [IDA]
Gene Ontology Cellular Component
Reconstituted Complex
An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator.
Publication
Neuropilin-1 exerts co-receptor function for TGF-beta-1 on the membrane of cancer cells and enhances responses to both latent and active TGF-beta.
Neuropilin (Nrp)-1 and Nrp-2 are multifunctional proteins frequently expressed by cancer cells and contribute to tumor progression by mechanisms that are not well understood. They are co-receptors for vascular endothelial growth factor and class 3 semaphorins, but recently we found that Nrp1 also binds latent and active transforming growth factor (TGF)-β1, and activates the latent form latency-associated peptide (LAP)-TGF-β1. Here, ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID