BAIT
WWTR1
2310058J06Rik, 2610021I22Rik, C78399, Taz
WW domain containing transcription regulator 1
GO Process (24)
GO Function (4)
GO Component (4)
Gene Ontology Biological Process
- SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [IMP]
- cilium morphogenesis [IMP]
- glomerulus development [IMP]
- hippo signaling [ISO]
- kidney morphogenesis [IMP]
- mesenchymal cell differentiation [IMP]
- multicellular organism growth [IMP]
- negative regulation of canonical Wnt signaling pathway [ISO]
- negative regulation of catenin import into nucleus [ISO]
- negative regulation of fat cell differentiation [IGI]
- negative regulation of protein kinase activity [ISO]
- negative regulation of protein phosphorylation [ISO]
- negative regulation of transcription from RNA polymerase II promoter [IGI]
- osteoblast differentiation [IGI, IMP]
- positive regulation of cell proliferation [ISO]
- positive regulation of epithelial to mesenchymal transition [ISO]
- positive regulation of transcription from RNA polymerase II promoter [IDA, IGI]
- protein ubiquitination [IDA]
- regulation of SMAD protein import into nucleus [ISO]
- regulation of canonical Wnt signaling pathway [IGI]
- regulation of metanephric nephron tubule epithelial cell differentiation [IGI]
- regulation of nucleic acid-templated transcription [ISO]
- regulation of transcription, DNA-templated [IDA]
- stem cell division [ISO]
Gene Ontology Molecular Function
Mus musculus
PREY
YWHAE
14-3-3E, HEL2, KCIP-1, MDCR, MDS
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon
GO Process (18)
GO Function (10)
GO Component (5)
Gene Ontology Biological Process
- G2/M transition of mitotic cell cycle [TAS]
- apoptotic process [TAS]
- apoptotic signaling pathway [TAS]
- hippo signaling [TAS]
- intracellular signal transduction [TAS]
- intrinsic apoptotic signaling pathway [TAS]
- membrane organization [TAS]
- membrane repolarization during cardiac muscle cell action potential [IC]
- mitotic cell cycle [TAS]
- negative regulation of peptidyl-serine dephosphorylation [IDA]
- neurotrophin TRK receptor signaling pathway [TAS]
- positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway [TAS]
- regulation of cysteine-type endopeptidase activity involved in apoptotic process [TAS]
- regulation of heart rate by cardiac conduction [IC]
- regulation of heart rate by hormone [NAS]
- regulation of membrane repolarization [IDA]
- regulation of potassium ion transmembrane transporter activity [IDA]
- substantia nigra development [IEP]
Gene Ontology Molecular Function- MHC class II protein complex binding [IDA]
- enzyme binding [IPI]
- histone deacetylase binding [IPI]
- ion channel binding [IPI]
- phosphoprotein binding [IPI]
- phosphoserine binding [IPI]
- poly(A) RNA binding [IDA]
- potassium channel regulator activity [IDA]
- protein binding [IPI]
- protein heterodimerization activity [IPI]
- MHC class II protein complex binding [IDA]
- enzyme binding [IPI]
- histone deacetylase binding [IPI]
- ion channel binding [IPI]
- phosphoprotein binding [IPI]
- phosphoserine binding [IPI]
- poly(A) RNA binding [IDA]
- potassium channel regulator activity [IDA]
- protein binding [IPI]
- protein heterodimerization activity [IPI]
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
The Crumbs complex couples cell density sensing to Hippo-dependent control of the TGF-β-SMAD pathway.
The Hippo pathway senses cell density information to control tissue growth by regulating the localization of the transcriptional regulators TAZ and YAP (TAZ/YAP). TAZ/YAP also regulate TGF-β-SMAD signaling, but whether this role is linked to cell density sensing is unknown. Here we demonstrate that TAZ/YAP dictate the localization of active SMAD complexes in response to cell density-mediated formation of polarity ... [more]
Dev. Cell Dec. 14, 2010; 19(6);831-44 [Pubmed: 21145499]
Throughput
- Low Throughput
Curated By
- BioGRID