YAP1
Gene Ontology Biological Process
- cell morphogenesis [IMP]
- cell proliferation [ISO]
- cellular response to DNA damage stimulus [ISO]
- cellular response to gamma radiation [ISO]
- cellular response to retinoic acid [IDA]
- contact inhibition [ISO]
- embryonic heart tube morphogenesis [IGI]
- hippo signaling [IGI]
- keratinocyte differentiation [IGI, IMP]
- lateral mesoderm development [IGI]
- negative regulation of epithelial cell differentiation [IDA]
- negative regulation of extrinsic apoptotic signaling pathway [IGI]
- negative regulation of nucleic acid-templated transcription [ISO]
- negative regulation of stem cell differentiation [IDA]
- notochord development [IGI]
- paraxial mesoderm development [IGI]
- positive regulation of canonical Wnt signaling pathway [IDA]
- positive regulation of cell proliferation [IDA, IMP]
- positive regulation of organ growth [IDA]
- positive regulation of stem cell maintenance [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IDA, IGI]
- regulation of canonical Wnt signaling pathway [IGI]
- regulation of cell proliferation [IGI]
- regulation of keratinocyte proliferation [IMP]
- regulation of metanephric nephron tubule epithelial cell differentiation [IGI]
- regulation of stem cell proliferation [IDA, IMP]
- regulation of transcription from RNA polymerase II promoter [IPI]
- somatic stem cell maintenance [IDA]
- transcription from RNA polymerase II promoter [IPI]
- vasculogenesis [IMP]
Gene Ontology Molecular Function- RNA polymerase II core promoter sequence-specific DNA binding [IDA]
- RNA polymerase II transcription factor binding transcription factor activity [IPI]
- chromatin binding [IDA]
- proline-rich region binding [IPI]
- protein C-terminus binding [IPI]
- protein binding [IPI]
- transcription coactivator activity [IDA, ISO]
- transcription corepressor activity [ISO]
- transcription regulatory region DNA binding [ISO]
- RNA polymerase II core promoter sequence-specific DNA binding [IDA]
- RNA polymerase II transcription factor binding transcription factor activity [IPI]
- chromatin binding [IDA]
- proline-rich region binding [IPI]
- protein C-terminus binding [IPI]
- protein binding [IPI]
- transcription coactivator activity [IDA, ISO]
- transcription corepressor activity [ISO]
- transcription regulatory region DNA binding [ISO]
MPDZ
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
The Crumbs complex couples cell density sensing to Hippo-dependent control of the TGF-β-SMAD pathway.
The Hippo pathway senses cell density information to control tissue growth by regulating the localization of the transcriptional regulators TAZ and YAP (TAZ/YAP). TAZ/YAP also regulate TGF-β-SMAD signaling, but whether this role is linked to cell density sensing is unknown. Here we demonstrate that TAZ/YAP dictate the localization of active SMAD complexes in response to cell density-mediated formation of polarity ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| YAP1 MPDZ | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | - | BioGRID | 1463643 | |
| YAP1 MPDZ | Reconstituted Complex Reconstituted Complex An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator. | High | - | BioGRID | - |
Curated By
- BioGRID