YAP1
Gene Ontology Biological Process
- cell morphogenesis [IMP]
- cell proliferation [ISO]
- cellular response to DNA damage stimulus [ISO]
- cellular response to gamma radiation [ISO]
- cellular response to retinoic acid [IDA]
- contact inhibition [ISO]
- embryonic heart tube morphogenesis [IGI]
- hippo signaling [IGI]
- keratinocyte differentiation [IGI, IMP]
- lateral mesoderm development [IGI]
- negative regulation of epithelial cell differentiation [IDA]
- negative regulation of extrinsic apoptotic signaling pathway [IGI]
- negative regulation of nucleic acid-templated transcription [ISO]
- negative regulation of stem cell differentiation [IDA]
- notochord development [IGI]
- paraxial mesoderm development [IGI]
- positive regulation of canonical Wnt signaling pathway [IDA]
- positive regulation of cell proliferation [IDA, IMP]
- positive regulation of organ growth [IDA]
- positive regulation of stem cell maintenance [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IDA, IGI]
- regulation of canonical Wnt signaling pathway [IGI]
- regulation of cell proliferation [IGI]
- regulation of keratinocyte proliferation [IMP]
- regulation of metanephric nephron tubule epithelial cell differentiation [IGI]
- regulation of stem cell proliferation [IDA, IMP]
- regulation of transcription from RNA polymerase II promoter [IPI]
- somatic stem cell maintenance [IDA]
- transcription from RNA polymerase II promoter [IPI]
- vasculogenesis [IMP]
Gene Ontology Molecular Function- RNA polymerase II core promoter sequence-specific DNA binding [IDA]
- RNA polymerase II transcription factor binding transcription factor activity [IPI]
- chromatin binding [IDA]
- proline-rich region binding [IPI]
- protein C-terminus binding [IPI]
- protein binding [IPI]
- transcription coactivator activity [IDA, ISO]
- transcription corepressor activity [ISO]
- transcription regulatory region DNA binding [ISO]
- RNA polymerase II core promoter sequence-specific DNA binding [IDA]
- RNA polymerase II transcription factor binding transcription factor activity [IPI]
- chromatin binding [IDA]
- proline-rich region binding [IPI]
- protein C-terminus binding [IPI]
- protein binding [IPI]
- transcription coactivator activity [IDA, ISO]
- transcription corepressor activity [ISO]
- transcription regulatory region DNA binding [ISO]
YWHAG
Gene Ontology Biological Process
- G2/M transition of mitotic cell cycle [TAS]
- apoptotic process [TAS]
- intrinsic apoptotic signaling pathway [TAS]
- membrane organization [TAS]
- mitotic cell cycle [TAS]
- negative regulation of protein kinase activity [NAS]
- negative regulation of protein serine/threonine kinase activity [NAS]
- positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway [TAS]
- regulation of neuron differentiation [IMP]
- regulation of signal transduction [NAS]
- regulation of synaptic plasticity [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
The Crumbs complex couples cell density sensing to Hippo-dependent control of the TGF-β-SMAD pathway.
The Hippo pathway senses cell density information to control tissue growth by regulating the localization of the transcriptional regulators TAZ and YAP (TAZ/YAP). TAZ/YAP also regulate TGF-β-SMAD signaling, but whether this role is linked to cell density sensing is unknown. Here we demonstrate that TAZ/YAP dictate the localization of active SMAD complexes in response to cell density-mediated formation of polarity ... [more]
Throughput
- Low Throughput
Related interactions
Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
---|---|---|---|---|---|---|
YAP1 YWHAG | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | - | BioGRID | 1462993 |
Curated By
- BioGRID