BAIT
STAT3
signal transducer and activator of transcription 3 (acute-phase response factor)
GO Process (42)
GO Function (13)
GO Component (7)
Gene Ontology Biological Process
- JAK-STAT cascade [TAS]
- JAK-STAT cascade involved in growth hormone signaling pathway [ISO, ISS]
- acute-phase response [IEP]
- aging [IEP]
- astrocyte differentiation [ISO, ISS]
- cell proliferation [ISO]
- cellular response to hormone stimulus [ISO]
- eating behavior [ISO, ISS]
- eye photoreceptor cell differentiation [ISO, ISS]
- glucose homeostasis [ISO, ISS]
- growth hormone receptor signaling pathway [ISO]
- interleukin-6-mediated signaling pathway [ISO, ISS]
- intracellular receptor signaling pathway [ISO]
- negative regulation of cell death [IMP]
- negative regulation of cell proliferation [ISO]
- negative regulation of glycolytic process [ISO]
- negative regulation of hydrogen peroxide biosynthetic process [IMP]
- negative regulation of neuron death [IMP]
- negative regulation of neuron migration [ISO]
- phosphorylation [ISO, ISS]
- positive regulation of ATP biosynthetic process [IMP]
- positive regulation of Notch signaling pathway [ISO, ISS]
- positive regulation of growth factor dependent skeletal muscle satellite cell proliferation [IMP]
- positive regulation of transcription from RNA polymerase II promoter [ISO]
- positive regulation of transcription, DNA-templated [ISO, ISS]
- protein import into nucleus [ISO, ISS]
- radial glial cell differentiation [ISO, ISS]
- regulation of mitochondrial membrane permeability [IMP]
- regulation of multicellular organism growth [ISO]
- regulation of transcription from RNA polymerase II promoter [ISS]
- regulation of transcription, DNA-templated [ISO]
- response to cytokine [IDA]
- response to drug [IEP]
- response to estradiol [IEP, ISO]
- response to ethanol [IEP]
- response to organic cyclic compound [IEP]
- response to organic substance [IEP]
- response to peptide hormone [IEP]
- sexual reproduction [ISO, ISS]
- stem cell maintenance [ISO]
- temperature homeostasis [ISO, ISS]
- transcription from RNA polymerase II promoter [ISO]
Gene Ontology Molecular Function- CCR5 chemokine receptor binding [IPI]
- DNA binding [IDA, ISO, ISS]
- RNA polymerase II repressing transcription factor binding [ISO]
- glucocorticoid receptor binding [IPI]
- ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity [ISO]
- protein dimerization activity [ISO, ISS]
- protein kinase binding [ISO, ISS]
- protein phosphatase binding [ISO]
- sequence-specific DNA binding [IDA, ISO]
- sequence-specific DNA binding RNA polymerase II transcription factor activity [ISO]
- sequence-specific DNA binding transcription factor activity [TAS]
- transcription factor binding [IPI, ISO]
- transcription regulatory region DNA binding [ISO]
- CCR5 chemokine receptor binding [IPI]
- DNA binding [IDA, ISO, ISS]
- RNA polymerase II repressing transcription factor binding [ISO]
- glucocorticoid receptor binding [IPI]
- ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity [ISO]
- protein dimerization activity [ISO, ISS]
- protein kinase binding [ISO, ISS]
- protein phosphatase binding [ISO]
- sequence-specific DNA binding [IDA, ISO]
- sequence-specific DNA binding RNA polymerase II transcription factor activity [ISO]
- sequence-specific DNA binding transcription factor activity [TAS]
- transcription factor binding [IPI, ISO]
- transcription regulatory region DNA binding [ISO]
Gene Ontology Cellular Component
Rattus norvegicus
PREY
PDIA3
ER60, ERp57, Grp58
protein disulfide isomerase family A, member 3
GO Process (3)
GO Function (2)
GO Component (7)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Rattus norvegicus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Cellular physiology of STAT3: Where's the cytoplasmic monomer?
In the standard model of cytokine-induced signal transducer and activator of transcription (STAT) protein family signaling to the cell nucleus, it is assumed that STAT3 is recruited to the cytoplasmic side of the cell surface receptor complex from within a cytosolic monomer pool. By using Superose-6 gel-filtration chromatography, we have discovered that there is little monomeric STAT3 (91 kDa) in ... [more]
J. Biol. Chem. Sep. 03, 1999; 274(36);25499-509 [Pubmed: 10464281]
Throughput
- Low Throughput
Curated By
- BioGRID