USP16
Gene Ontology Biological Process
- cellular response to DNA damage stimulus [ISO]
- histone H2A K63-linked deubiquitination [IBA, ISO]
- histone deubiquitination [ISO]
- mitotic nuclear division [ISO]
- monoubiquitinated histone H2A deubiquitination [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IMP]
- positive regulation of transcription, DNA-templated [ISO]
- positive regulation of translational elongation [ISO]
- proteasome-mediated ubiquitin-dependent protein catabolic process [IBA]
- protein homotetramerization [ISO]
- proteolysis [ISO]
- regulation of proteasomal protein catabolic process [IBA]
- regulation of transcription from RNA polymerase II promoter [IDA]
Gene Ontology Molecular Function
HIST2H2AC
Gene Ontology Cellular Component
Biochemical Activity (Deubiquitination)
An interaction is inferred from the biochemical effect of one protein upon another, for example, GTP-GDP exchange activity or phosphorylation of a substrate by a kinase. The bait protein executes the activity on the substrate hit protein. A Modification value is recorded for interactions of this type with the possible values Phosphorylation, Ubiquitination, Sumoylation, Dephosphorylation, Methylation, Prenylation, Acetylation, Deubiquitination, Proteolytic Processing, Glucosylation, Nedd(Rub1)ylation, Deacetylation, No Modification, Demethylation.
Publication
The Aurora B Kinase and the Polycomb Protein Ring1B Combine to Regulate Active Promoters in Quiescent Lymphocytes.
Reversible cellular quiescence is critical for developmental processes in metazoan organisms and is characterized by a reduction in cell size and transcriptional activity. We show that the Aurora B kinase and the polycomb protein Ring1B have essential roles in regulating transcriptionally active genes in quiescent lymphocytes. Ring1B and Aurora B bind to a wide range of active promoters in resting ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID