AGTR1A
Gene Ontology Biological Process
- G-protein coupled receptor signaling pathway [IC, ISO]
- Rho protein signal transduction [ISO]
- activation of Janus kinase activity [ISO]
- angiotensin-activated signaling pathway [ISO]
- blood vessel development [IGI]
- brain renin-angiotensin system [IMP]
- calcium-mediated signaling [ISO]
- cell chemotaxis [ISO]
- cellular response to dexamethasone stimulus [ISO]
- dopamine biosynthetic process [ISO]
- drinking behavior [IGI, IMP, ISO]
- heart development [IMP]
- inflammatory response [IGI]
- kidney development [IGI, IMP, ISO]
- negative regulation of neuron apoptotic process [IMP]
- negative regulation of smooth muscle cell apoptotic process [IMP]
- phospholipase C-activating G-protein coupled receptor signaling pathway [ISO]
- phospholipase C-activating angiotensin-activated signaling pathway [IDA, ISO]
- positive regulation of blood pressure [IDA, IGI, IMP, ISO]
- positive regulation of branching involved in ureteric bud morphogenesis [ISO]
- positive regulation of cell proliferation [IMP, ISO]
- positive regulation of cellular protein metabolic process [ISO]
- positive regulation of cholesterol esterification [ISO]
- positive regulation of cytokine secretion [IMP]
- positive regulation of cytosolic calcium ion concentration [ISO]
- positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway [ISO]
- positive regulation of phospholipase A2 activity [ISO]
- positive regulation of receptor recycling [ISO]
- positive regulation of superoxide anion generation [ISO]
- regulation of pH [ISO]
- regulation of renal output by angiotensin [IMP]
- regulation of smooth muscle cell apoptotic process [IGI]
- regulation of systemic arterial blood pressure by circulatory renin-angiotensin [IGI]
- regulation of vasoconstriction [ISO]
- renin secretion into blood stream [IMP]
- renin-angiotensin regulation of aldosterone production [IMP, ISO]
- response to estrogen [ISO]
- vasoconstriction [ISO]
Gene Ontology Molecular Function- D1 dopamine receptor binding [ISO]
- G-protein alpha-subunit binding [ISO]
- angiotensin type I receptor activity [IDA, ISO]
- angiotensin type II receptor activity [ISO]
- bradykinin receptor binding [ISO]
- peptide hormone binding [ISO]
- protein binding [IPI]
- protein heterodimerization activity [ISO]
- protein kinase binding [ISO]
- protein self-association [ISO]
- D1 dopamine receptor binding [ISO]
- G-protein alpha-subunit binding [ISO]
- angiotensin type I receptor activity [IDA, ISO]
- angiotensin type II receptor activity [ISO]
- bradykinin receptor binding [ISO]
- peptide hormone binding [ISO]
- protein binding [IPI]
- protein heterodimerization activity [ISO]
- protein kinase binding [ISO]
- protein self-association [ISO]
Gene Ontology Cellular Component
- Golgi apparatus [ISO]
- basolateral plasma membrane [ISO]
- cell [IMP]
- cytoplasm [IDA]
- cytoplasmic vesicle [ISO]
- cytosol [ISO]
- dendrite [ISO]
- endomembrane system [ISO]
- endosome [IDA]
- membrane [ISO]
- organelle outer membrane [ISO]
- plasma membrane [IDA, ISO]
- recycling endosome [ISO]
- vesicle lumen [ISO]
- vesicle membrane [ISO]
AGTRAP
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Cloning and characterization of ATRAP, a novel protein that interacts with the angiotensin II type 1 receptor.
The carboxyl-terminal cytoplasmic domain of the angiotensin II type 1 (AT1) receptor has recently been shown to interact with several classes of cytoplasmic proteins that regulate different aspects of AT1 receptor physiology. Employing yeast two-hybrid screening of a mouse kidney cDNA library with the carboxyl-terminal cytoplasmic domain of the murine AT1a receptor as a bait, we have isolated a novel ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| AGTR1A AGTRAP | Reconstituted Complex Reconstituted Complex An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator. | Low | - | BioGRID | - | |
| AGTR1A AGTRAP | Two-hybrid Two-hybrid Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation. | Low | - | BioGRID | - |
Curated By
- BioGRID