INSR
Gene Ontology Biological Process
- G-protein coupled receptor signaling pathway [IDA]
- activation of MAPK activity [IMP]
- activation of protein kinase B activity [IDA]
- activation of protein kinase activity [IMP]
- cellular response to insulin stimulus [IDA]
- glucose homeostasis [IMP]
- heart morphogenesis [IMP]
- insulin receptor signaling pathway [IDA, TAS]
- peptidyl-tyrosine phosphorylation [IDA]
- positive regulation of DNA replication [IMP]
- positive regulation of MAPK cascade [IMP]
- positive regulation of cell migration [IMP]
- positive regulation of cell proliferation [IC, IDA]
- positive regulation of developmental growth [IMP]
- positive regulation of glucose import [IDA, NAS]
- positive regulation of glycogen biosynthetic process [IDA]
- positive regulation of glycolytic process [IMP]
- positive regulation of mitosis [IMP]
- positive regulation of nitric oxide biosynthetic process [IMP]
- positive regulation of protein kinase B signaling [IMP]
- positive regulation of protein phosphorylation [IDA]
- positive regulation of respiratory burst [IDA]
- protein autophosphorylation [IDA, IMP]
- protein heterotetramerization [IDA]
- regulation of embryonic development [IMP]
- regulation of transcription, DNA-templated [IMP]
- signal transduction by phosphorylation [IDA]
- transformation of host cell by virus [IMP]
Gene Ontology Molecular Function- ATP binding [IDA]
- GTP binding [IDA]
- PTB domain binding [IPI]
- insulin binding [IDA, IPI]
- insulin receptor substrate binding [IPI]
- insulin-activated receptor activity [IDA]
- insulin-like growth factor I binding [IPI]
- insulin-like growth factor II binding [IPI]
- insulin-like growth factor receptor binding [IDA]
- phosphatidylinositol 3-kinase binding [IPI]
- protein binding [IPI]
- protein tyrosine kinase activity [IDA, IMP]
- receptor signaling protein tyrosine kinase activity [IDA]
- ATP binding [IDA]
- GTP binding [IDA]
- PTB domain binding [IPI]
- insulin binding [IDA, IPI]
- insulin receptor substrate binding [IPI]
- insulin-activated receptor activity [IDA]
- insulin-like growth factor I binding [IPI]
- insulin-like growth factor II binding [IPI]
- insulin-like growth factor receptor binding [IDA]
- phosphatidylinositol 3-kinase binding [IPI]
- protein binding [IPI]
- protein tyrosine kinase activity [IDA, IMP]
- receptor signaling protein tyrosine kinase activity [IDA]
Gene Ontology Cellular Component
GRB2
Gene Ontology Biological Process
- Ras protein signal transduction [TAS]
- aging [IPI]
- anatomical structure formation involved in morphogenesis [ISO]
- branching involved in labyrinthine layer morphogenesis [ISO]
- cell differentiation [ISO]
- cellular response to ionizing radiation [ISO]
- fibroblast growth factor receptor signaling pathway [ISO]
- insulin receptor signaling pathway [ISO]
- positive regulation of actin filament polymerization [ISO]
- positive regulation of reactive oxygen species metabolic process [ISO]
- positive regulation of signal transduction [ISO]
- protein heterooligomerization [IDA]
- receptor internalization [ISO]
- regulation of MAPK cascade [ISO]
- signal transduction in response to DNA damage [ISO]
Gene Ontology Molecular Function- SH3 domain binding [ISO, ISS]
- SH3/SH2 adaptor activity [ISO]
- ephrin receptor binding [ISO]
- epidermal growth factor receptor binding [IPI, ISO, ISS]
- identical protein binding [ISO]
- insulin receptor substrate binding [IPI, ISO]
- neurotrophin TRKA receptor binding [ISO]
- phosphoprotein binding [IPI]
- phosphotyrosine binding [IPI]
- poly(A) RNA binding [ISO]
- protein binding [IPI]
- protein domain specific binding [IPI, ISO]
- protein kinase binding [ISO]
- protein phosphatase binding [ISO]
- SH3 domain binding [ISO, ISS]
- SH3/SH2 adaptor activity [ISO]
- ephrin receptor binding [ISO]
- epidermal growth factor receptor binding [IPI, ISO, ISS]
- identical protein binding [ISO]
- insulin receptor substrate binding [IPI, ISO]
- neurotrophin TRKA receptor binding [ISO]
- phosphoprotein binding [IPI]
- phosphotyrosine binding [IPI]
- poly(A) RNA binding [ISO]
- protein binding [IPI]
- protein domain specific binding [IPI, ISO]
- protein kinase binding [ISO]
- protein phosphatase binding [ISO]
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
PC12 cells overexpressing the insulin receptor undergo insulin-dependent neuronal differentiation.
Stimulation of phaeochromocytoma PC12 cells by nerve growth factor leads to growth arrest and neuronal differentiation, whereas insulin induces various metabolic responses such as metabolism of glucose and lipids. Moreover, both insulin and epidermal growth factor stimulate the proliferation of PC12 cells. In spite of their different biological effects, nerve growth factor, insulin and epidermal growth factor induce very similar ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID