BAIT
PRKCZ
14-3-3-zetaisoform, Pkcz, r14-3-3
protein kinase C, zeta
GO Process (43)
GO Function (10)
GO Component (21)
Gene Ontology Biological Process
- actin cytoskeleton reorganization [IMP]
- activation of phospholipase D activity [IMP]
- activation of protein kinase B activity [IMP]
- cell migration [IMP]
- cell surface receptor signaling pathway [IMP]
- cellular protein localization [IMP]
- cellular response to insulin stimulus [IMP]
- establishment of cell polarity [IMP]
- insulin receptor signaling pathway [IMP]
- intracellular signal transduction [IDA]
- long-term memory [IMP]
- long-term synaptic potentiation [IMP]
- membrane depolarization [IMP]
- membrane hyperpolarization [IMP]
- microtubule cytoskeleton organization [ISO]
- negative regulation of apoptotic process [IDA]
- negative regulation of hydrolase activity [IDA]
- negative regulation of insulin receptor signaling pathway [ISO]
- negative regulation of peptidyl-tyrosine phosphorylation [ISO]
- negative regulation of protein complex assembly [ISO]
- neuron projection extension [ISO]
- peptidyl-serine phosphorylation [IDA, ISO]
- positive regulation of ERK1 and ERK2 cascade [IMP, ISO, ISS]
- positive regulation of NF-kappaB transcription factor activity [IMP]
- positive regulation of T-helper 2 cell cytokine production [ISO, ISS]
- positive regulation of T-helper 2 cell differentiation [ISO, ISS]
- positive regulation of cell proliferation [IMP]
- positive regulation of cell-matrix adhesion [IMP]
- positive regulation of excitatory postsynaptic membrane potential [IDA]
- positive regulation of glucose import [IMP]
- positive regulation of insulin receptor signaling pathway [IMP]
- positive regulation of interleukin-10 secretion [ISO, ISS]
- positive regulation of interleukin-13 secretion [ISO, ISS]
- positive regulation of interleukin-4 production [ISO, ISS]
- positive regulation of interleukin-5 secretion [ISO, ISS]
- positive regulation of protein transport [IMP]
- positive regulation of synaptic transmission [IMP]
- protein heterooligomerization [IPI]
- protein kinase C signaling [IMP]
- protein localization to plasma membrane [ISO]
- protein phosphorylation [IDA, ISO]
- signal transduction [IDA]
- vesicle transport along microtubule [IMP]
Gene Ontology Molecular Function- 14-3-3 protein binding [IPI]
- ATP binding [IDA]
- phospholipase binding [IPI]
- potassium channel regulator activity [IMP]
- protein binding [IPI]
- protein domain specific binding [IPI]
- protein kinase C activity [IDA]
- protein kinase activity [ISO, TAS]
- protein kinase binding [IPI]
- protein serine/threonine kinase activity [IDA, ISO]
- 14-3-3 protein binding [IPI]
- ATP binding [IDA]
- phospholipase binding [IPI]
- potassium channel regulator activity [IMP]
- protein binding [IPI]
- protein domain specific binding [IPI]
- protein kinase C activity [IDA]
- protein kinase activity [ISO, TAS]
- protein kinase binding [IPI]
- protein serine/threonine kinase activity [IDA, ISO]
Gene Ontology Cellular Component
- apical cortex [ISO]
- apical plasma membrane [ISO]
- axon hillock [ISO]
- cell cortex [ISO]
- cell leading edge [IDA]
- cell-cell junction [ISO, ISS]
- cytoplasm [IDA, ISO]
- cytosol [IDA, TAS]
- extracellular vesicular exosome [ISO]
- filamentous actin [IDA]
- intracellular membrane-bounded organelle [IDA]
- membrane raft [IDA]
- microtubule organizing center [ISO]
- myelin sheath abaxonal region [ISO]
- nuclear envelope [ISO]
- nuclear matrix [ISO]
- nucleus [ISO]
- perinuclear region of cytoplasm [IDA]
- plasma membrane [IDA, ISO]
- protein complex [IDA, ISO]
- tight junction [ISO]
Rattus norvegicus
PREY
MAP2K1
Mek1
mitogen activated protein kinase kinase 1
GO Process (35)
GO Function (9)
GO Component (18)
Gene Ontology Biological Process
- Golgi inheritance [IMP]
- MAPK cascade [IMP, ISO]
- activation of MAPK activity [IDA, ISO, TAS]
- cell cycle arrest [ISO]
- cell motility [ISO]
- cell proliferation [IDA]
- cellular senescence [ISO]
- intracellular signal transduction [TAS]
- keratinocyte differentiation [ISO]
- labyrinthine layer development [ISO]
- melanosome transport [IDA]
- mitotic nuclear division [IDA]
- negative regulation of cell proliferation [ISO]
- negative regulation of homotypic cell-cell adhesion [IMP]
- neuron differentiation [IMP, ISO]
- neuron projection morphogenesis [IMP]
- peptidyl-tyrosine dephosphorylation [ISO]
- placenta blood vessel development [ISO]
- positive regulation of Ras GTPase activity [IMP]
- positive regulation of Ras protein signal transduction [IMP]
- positive regulation of cell differentiation [ISO]
- positive regulation of cell migration [IMP]
- positive regulation of gene expression [ISO]
- positive regulation of protein serine/threonine kinase activity [ISO]
- positive regulation of transcription elongation from RNA polymerase II promoter [IMP]
- protein heterooligomerization [IPI]
- protein phosphorylation [IDA, ISO, TAS]
- regulation of Golgi inheritance [TAS]
- regulation of early endosome to late endosome transport [TAS]
- regulation of stress-activated MAPK cascade [TAS]
- regulation of vascular smooth muscle contraction [IMP]
- response to axon injury [IMP]
- response to glucocorticoid [IDA]
- response to oxidative stress [IDA]
- vesicle transport along microtubule [IDA]
Gene Ontology Molecular Function- ATP binding [IDA]
- MAP kinase kinase activity [IDA, IMP, ISO, TAS]
- Ras GTPase binding [IPI]
- mitogen-activated protein kinase kinase kinase binding [IDA, IPI]
- protein binding [IPI]
- protein kinase binding [IPI]
- protein serine/threonine kinase activator activity [ISO]
- protein serine/threonine/tyrosine kinase activity [TAS]
- receptor signaling protein tyrosine phosphatase activity [ISO]
- ATP binding [IDA]
- MAP kinase kinase activity [IDA, IMP, ISO, TAS]
- Ras GTPase binding [IPI]
- mitogen-activated protein kinase kinase kinase binding [IDA, IPI]
- protein binding [IPI]
- protein kinase binding [IPI]
- protein serine/threonine kinase activator activity [ISO]
- protein serine/threonine/tyrosine kinase activity [TAS]
- receptor signaling protein tyrosine phosphatase activity [ISO]
Gene Ontology Cellular Component
- Golgi apparatus [IDA, TAS]
- axon [IDA]
- cell cortex [IDA]
- cytoplasm [ISO]
- cytosol [IDA, TAS]
- dendrite [IDA]
- dendrite cytoplasm [IDA]
- early endosome [TAS]
- endoplasmic reticulum [ISO]
- extracellular vesicular exosome [ISO]
- focal adhesion [TAS]
- late endosome [TAS]
- microtubule [IDA]
- mitochondrion [TAS]
- nucleus [TAS]
- perikaryon [IDA]
- perinuclear region of cytoplasm [IDA]
- plasma membrane [IDA, ISO]
Rattus norvegicus
Biochemical Activity (Phosphorylation)
An interaction is inferred from the biochemical effect of one protein upon another, for example, GTP-GDP exchange activity or phosphorylation of a substrate by a kinase. The bait protein executes the activity on the substrate hit protein. A Modification value is recorded for interactions of this type with the possible values Phosphorylation, Ubiquitination, Sumoylation, Dephosphorylation, Methylation, Prenylation, Acetylation, Deubiquitination, Proteolytic Processing, Glucosylation, Nedd(Rub1)ylation, Deacetylation, No Modification, Demethylation.
Publication
zeta PKC induces phosphorylation and inactivation of I kappa B-alpha in vitro.
The zeta isotype of protein kinase C (zeta PKC), a distinct PKC unable to bind phorbol esters, is required during NF-kappa B activation as well as in mitogenic signalling in Xenopus oocytes and mammalian cells. To investigate the mechanism(s) for control of cellular functions by zeta PKC, this enzyme was expressed in Escherichia coli as a fusion protein with maltose ... [more]
EMBO J. Jun. 15, 1994; 13(12);2842-8 [Pubmed: 8026469]
Throughput
- Low Throughput
Curated By
- BioGRID