MAP2K1
Gene Ontology Biological Process
- Golgi inheritance [IMP]
- MAPK cascade [IMP, ISO]
- activation of MAPK activity [IDA, ISO, TAS]
- cell cycle arrest [ISO]
- cell motility [ISO]
- cell proliferation [IDA]
- cellular senescence [ISO]
- intracellular signal transduction [TAS]
- keratinocyte differentiation [ISO]
- labyrinthine layer development [ISO]
- melanosome transport [IDA]
- mitotic nuclear division [IDA]
- negative regulation of cell proliferation [ISO]
- negative regulation of homotypic cell-cell adhesion [IMP]
- neuron differentiation [IMP, ISO]
- neuron projection morphogenesis [IMP]
- peptidyl-tyrosine dephosphorylation [ISO]
- placenta blood vessel development [ISO]
- positive regulation of Ras GTPase activity [IMP]
- positive regulation of Ras protein signal transduction [IMP]
- positive regulation of cell differentiation [ISO]
- positive regulation of cell migration [IMP]
- positive regulation of gene expression [ISO]
- positive regulation of protein serine/threonine kinase activity [ISO]
- positive regulation of transcription elongation from RNA polymerase II promoter [IMP]
- protein heterooligomerization [IPI]
- protein phosphorylation [IDA, ISO, TAS]
- regulation of Golgi inheritance [TAS]
- regulation of early endosome to late endosome transport [TAS]
- regulation of stress-activated MAPK cascade [TAS]
- regulation of vascular smooth muscle contraction [IMP]
- response to axon injury [IMP]
- response to glucocorticoid [IDA]
- response to oxidative stress [IDA]
- vesicle transport along microtubule [IDA]
Gene Ontology Molecular Function- ATP binding [IDA]
- MAP kinase kinase activity [IDA, IMP, ISO, TAS]
- Ras GTPase binding [IPI]
- mitogen-activated protein kinase kinase kinase binding [IDA, IPI]
- protein binding [IPI]
- protein kinase binding [IPI]
- protein serine/threonine kinase activator activity [ISO]
- protein serine/threonine/tyrosine kinase activity [TAS]
- receptor signaling protein tyrosine phosphatase activity [ISO]
- ATP binding [IDA]
- MAP kinase kinase activity [IDA, IMP, ISO, TAS]
- Ras GTPase binding [IPI]
- mitogen-activated protein kinase kinase kinase binding [IDA, IPI]
- protein binding [IPI]
- protein kinase binding [IPI]
- protein serine/threonine kinase activator activity [ISO]
- protein serine/threonine/tyrosine kinase activity [TAS]
- receptor signaling protein tyrosine phosphatase activity [ISO]
Gene Ontology Cellular Component
- Golgi apparatus [IDA, TAS]
- axon [IDA]
- cell cortex [IDA]
- cytoplasm [ISO]
- cytosol [IDA, TAS]
- dendrite [IDA]
- dendrite cytoplasm [IDA]
- early endosome [TAS]
- endoplasmic reticulum [ISO]
- extracellular vesicular exosome [ISO]
- focal adhesion [TAS]
- late endosome [TAS]
- microtubule [IDA]
- mitochondrion [TAS]
- nucleus [TAS]
- perikaryon [IDA]
- perinuclear region of cytoplasm [IDA]
- plasma membrane [IDA, ISO]
MAPK1-B
Biochemical Activity (Phosphorylation)
An interaction is inferred from the biochemical effect of one protein upon another, for example, GTP-GDP exchange activity or phosphorylation of a substrate by a kinase. The bait protein executes the activity on the substrate hit protein. A Modification value is recorded for interactions of this type with the possible values Phosphorylation, Ubiquitination, Sumoylation, Dephosphorylation, Methylation, Prenylation, Acetylation, Deubiquitination, Proteolytic Processing, Glucosylation, Nedd(Rub1)ylation, Deacetylation, No Modification, Demethylation.
Publication
zeta PKC induces phosphorylation and inactivation of I kappa B-alpha in vitro.
The zeta isotype of protein kinase C (zeta PKC), a distinct PKC unable to bind phorbol esters, is required during NF-kappa B activation as well as in mitogenic signalling in Xenopus oocytes and mammalian cells. To investigate the mechanism(s) for control of cellular functions by zeta PKC, this enzyme was expressed in Escherichia coli as a fusion protein with maltose ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID