BAIT
EGFR
ERBB1, ErbB-1, Errp
epidermal growth factor receptor
GO Process (72)
GO Function (19)
GO Component (15)
Gene Ontology Biological Process
- activation of MAPKK activity [IMP]
- astrocyte activation [IMP]
- cell morphogenesis [ISO]
- cell proliferation [ISO]
- cell surface receptor signaling pathway [ISO]
- cellular response to amino acid stimulus [ISO]
- cellular response to dexamethasone stimulus [IEP]
- cellular response to drug [IEP]
- cellular response to epidermal growth factor stimulus [IDA]
- cellular response to estradiol stimulus [ISO]
- cellular response to growth factor stimulus [IEP]
- cellular response to mechanical stimulus [IEP]
- cerebral cortex cell migration [ISO]
- circadian rhythm [IEP]
- digestive tract morphogenesis [ISO]
- diterpenoid metabolic process [IEP]
- embryonic placenta development [ISO]
- epidermal growth factor receptor signaling pathway [IDA, IMP, ISO]
- epidermis development [ISO]
- hair follicle development [ISO]
- hydrogen peroxide metabolic process [IEP]
- intracellular signal transduction [IDA]
- learning or memory [IDA]
- liver development [IEP]
- lung development [IEP]
- magnesium ion homeostasis [IMP]
- morphogenesis of an epithelial fold [ISO]
- negative regulation of apoptotic process [IMP, ISO]
- negative regulation of mitotic cell cycle [IMP]
- negative regulation of protein catabolic process [ISO]
- neuron projection morphogenesis [IMP]
- ovulation cycle [IMP]
- peptidyl-tyrosine phosphorylation [ISO]
- positive regulation of DNA repair [ISO]
- positive regulation of DNA replication [ISO]
- positive regulation of ERK1 and ERK2 cascade [ISO]
- positive regulation of MAP kinase activity [ISO]
- positive regulation of catenin import into nucleus [ISO]
- positive regulation of cell migration [ISO]
- positive regulation of cell proliferation [ISO]
- positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle [ISO]
- positive regulation of epithelial cell proliferation [ISO]
- positive regulation of fibroblast proliferation [ISO]
- positive regulation of inflammatory response [IMP]
- positive regulation of nitric oxide biosynthetic process [ISO]
- positive regulation of phosphorylation [ISO]
- positive regulation of protein kinase B signaling [ISO]
- positive regulation of protein phosphorylation [ISO]
- positive regulation of smooth muscle cell proliferation [IMP]
- positive regulation of superoxide anion generation [IMP]
- positive regulation of synaptic transmission, glutamatergic [IMP]
- positive regulation of transcription from RNA polymerase II promoter [ISO]
- positive regulation of vasoconstriction [IMP]
- positive regulation of vasodilation [IMP]
- protein autophosphorylation [IDA, ISO]
- regulation of cell proliferation [ISO]
- regulation of nitric-oxide synthase activity [ISO]
- regulation of peptidyl-tyrosine phosphorylation [ISO]
- response to UV-A [ISO]
- response to calcium ion [IMP]
- response to cobalamin [IEP]
- response to estradiol [IEP]
- response to hydroxyisoflavone [IEP]
- response to lipid [IEP]
- response to organic cyclic compound [IEP]
- response to osmotic stress [IEP]
- response to oxidative stress [IEP]
- salivary gland morphogenesis [ISO]
- signal transduction [IDA, ISO]
- single organismal cell-cell adhesion [ISO]
- tongue development [IEP]
- translation [IDA]
Gene Ontology Molecular Function- actin filament binding [ISO]
- chromatin binding [ISO]
- enzyme binding [ISO]
- epidermal growth factor binding [IMP]
- epidermal growth factor-activated receptor activity [IDA, IMP, ISO, TAS]
- glycoprotein binding [IPI]
- identical protein binding [ISO]
- integrin binding [IPI]
- kinase activity [ISO]
- nitric-oxide synthase regulator activity [ISO]
- protein binding [IPI]
- protein heterodimerization activity [IPI, ISO]
- protein kinase binding [IPI]
- protein phosphatase binding [ISO]
- protein tyrosine kinase activity [ISO]
- receptor binding [IPI]
- signal transducer activity [ISO]
- transmembrane signaling receptor activity [ISO]
- ubiquitin protein ligase binding [ISO]
- actin filament binding [ISO]
- chromatin binding [ISO]
- enzyme binding [ISO]
- epidermal growth factor binding [IMP]
- epidermal growth factor-activated receptor activity [IDA, IMP, ISO, TAS]
- glycoprotein binding [IPI]
- identical protein binding [ISO]
- integrin binding [IPI]
- kinase activity [ISO]
- nitric-oxide synthase regulator activity [ISO]
- protein binding [IPI]
- protein heterodimerization activity [IPI, ISO]
- protein kinase binding [IPI]
- protein phosphatase binding [ISO]
- protein tyrosine kinase activity [ISO]
- receptor binding [IPI]
- signal transducer activity [ISO]
- transmembrane signaling receptor activity [ISO]
- ubiquitin protein ligase binding [ISO]
Gene Ontology Cellular Component
- apical plasma membrane [IDA]
- basolateral plasma membrane [IDA, ISO]
- cell surface [IDA]
- cytoplasm [ISO]
- endocytic vesicle [IDA, ISO]
- endosome [IDA, ISO]
- endosome membrane [ISO]
- focal adhesion [ISO]
- intracellular [ISO]
- membrane [ISO]
- membrane raft [ISO]
- nucleus [IDA, ISO]
- perinuclear region of cytoplasm [ISO]
- plasma membrane [IDA, ISO]
- receptor complex [ISO]
Rattus norvegicus
PREY
GRB2
growth factor receptor bound protein 2
GO Process (15)
GO Function (14)
GO Component (14)
Gene Ontology Biological Process
- Ras protein signal transduction [TAS]
- aging [IPI]
- anatomical structure formation involved in morphogenesis [ISO]
- branching involved in labyrinthine layer morphogenesis [ISO]
- cell differentiation [ISO]
- cellular response to ionizing radiation [ISO]
- fibroblast growth factor receptor signaling pathway [ISO]
- insulin receptor signaling pathway [ISO]
- positive regulation of actin filament polymerization [ISO]
- positive regulation of reactive oxygen species metabolic process [ISO]
- positive regulation of signal transduction [ISO]
- protein heterooligomerization [IDA]
- receptor internalization [ISO]
- regulation of MAPK cascade [ISO]
- signal transduction in response to DNA damage [ISO]
Gene Ontology Molecular Function- SH3 domain binding [ISO, ISS]
- SH3/SH2 adaptor activity [ISO]
- ephrin receptor binding [ISO]
- epidermal growth factor receptor binding [IPI, ISO, ISS]
- identical protein binding [ISO]
- insulin receptor substrate binding [IPI, ISO]
- neurotrophin TRKA receptor binding [ISO]
- phosphoprotein binding [IPI]
- phosphotyrosine binding [IPI]
- poly(A) RNA binding [ISO]
- protein binding [IPI]
- protein domain specific binding [IPI, ISO]
- protein kinase binding [ISO]
- protein phosphatase binding [ISO]
- SH3 domain binding [ISO, ISS]
- SH3/SH2 adaptor activity [ISO]
- ephrin receptor binding [ISO]
- epidermal growth factor receptor binding [IPI, ISO, ISS]
- identical protein binding [ISO]
- insulin receptor substrate binding [IPI, ISO]
- neurotrophin TRKA receptor binding [ISO]
- phosphoprotein binding [IPI]
- phosphotyrosine binding [IPI]
- poly(A) RNA binding [ISO]
- protein binding [IPI]
- protein domain specific binding [IPI, ISO]
- protein kinase binding [ISO]
- protein phosphatase binding [ISO]
Gene Ontology Cellular Component
Rattus norvegicus
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Cyclic AMP induces transactivation of the receptors for epidermal growth factor and nerve growth factor, thereby modulating activation of MAP kinase, Akt, and neurite outgrowth in PC12 cells.
In PC12 cells, a well studied model for neuronal differentiation, an elevation in the intracellular cAMP level increases cell survival, stimulates neurite outgrowth, and causes activation of extracellular signal-regulated protein kinase 1 and 2 (ERK1/2). Here we show that an increase in the intracellular cAMP concentration induces tyrosine phosphorylation of two receptor tyrosine kinases, i.e. the epidermal growth factor (EGF) ... [more]
J. Biol. Chem. Nov. 15, 2002; 277(46);43623-30 [Pubmed: 12218049]
Throughput
- Low Throughput
Additional Notes
- interactions increased by forskolin
Curated By
- BioGRID