BAIT
SUMO2
HSMT3, SMT3B, SMT3H2, SUMO3, Smt3A
small ubiquitin-like modifier 2
GO Process (4)
GO Function (3)
GO Component (3)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Homo sapiens
PREY
TOPORS
LUN, P53BP3, RP31, TP53BPL, RP11-205M20.5
topoisomerase I binding, arginine/serine-rich, E3 ubiquitin protein ligase
GO Process (16)
GO Function (6)
GO Component (11)
Gene Ontology Biological Process
- cellular response to DNA damage stimulus [IDA]
- intrinsic apoptotic signaling pathway in response to DNA damage [IDA]
- maintenance of protein location in nucleus [IDA]
- negative regulation of apoptotic process [ISS]
- photoreceptor cell outer segment organization [ISS]
- positive regulation of ubiquitin-protein transferase activity [IDA]
- proteasome-mediated ubiquitin-dependent protein catabolic process [IMP]
- protein K48-linked ubiquitination [IDA]
- protein localization to nucleus [IMP]
- protein monoubiquitination [IDA]
- protein sumoylation [IDA, IMP]
- retina layer formation [ISS]
- retinal cone cell development [ISS]
- retinal rod cell development [ISS]
- transcription, DNA-templated [NAS]
- ubiquitin-dependent protein catabolic process [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Specification of SUMO1- and SUMO2-interacting motifs.
SUMO proteins are ubiquitin-related modifiers implicated in the regulation of gene transcription, cell cycle, DNA repair, and protein localization. The molecular mechanisms by which the sumoylation of target proteins regulates diverse cellular functions remain poorly understood. Here we report isolation and characterization of SUMO1- and SUMO2-binding motifs. Using yeast two-hybrid system, bioinformatics, and NMR spectroscopy we define a common SUMO-interacting ... [more]
J. Biol. Chem. Jun. 09, 2006; 281(23);16117-27 [Pubmed: 16524884]
Throughput
- Low Throughput
Additional Notes
- #LPPI
- Likely protein-protein interaction
Curated By
- BioGRID