DNAJB2
Gene Ontology Biological Process
- ER-associated ubiquitin-dependent protein catabolic process [IDA]
- negative regulation of cell growth [IGI]
- negative regulation of cell proliferation [IGI]
- negative regulation of inclusion body assembly [IDA]
- negative regulation of protein deubiquitination [IDA]
- positive regulation of proteasomal ubiquitin-dependent protein catabolic process [IDA]
- positive regulation of protein ubiquitination [IDA]
- protein folding [TAS]
- protein refolding [IDA]
- response to unfolded protein [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
SOD1
Gene Ontology Biological Process
- activation of MAPK activity [IDA]
- aging [IMP]
- anterograde axon cargo transport [IMP]
- auditory receptor cell stereocilium organization [IMP]
- cell aging [ISO]
- cellular iron ion homeostasis [IMP]
- embryo implantation [IMP]
- glutathione metabolic process [IMP]
- heart contraction [IMP, ISO]
- hydrogen peroxide biosynthetic process [IMP, ISO]
- locomotory behavior [IMP]
- muscle cell cellular homeostasis [IMP]
- myeloid cell homeostasis [IGI, IMP]
- negative regulation of apoptotic process [IDA, IMP, ISO]
- negative regulation of cholesterol biosynthetic process [ISO]
- negative regulation of neuron apoptotic process [IMP]
- neurofilament cytoskeleton organization [IGI, IMP]
- ovarian follicle development [IMP]
- oxidation-reduction process [IMP]
- peripheral nervous system myelin maintenance [IMP]
- positive regulation of catalytic activity [ISO]
- positive regulation of cytokine production [ISO]
- positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway [ISO]
- positive regulation of superoxide anion generation [ISO]
- reactive oxygen species metabolic process [ISO]
- regulation of Rac GTPase activity [ISO]
- regulation of blood pressure [IMP]
- regulation of mitochondrial membrane potential [ISO]
- regulation of multicellular organism growth [IMP]
- regulation of protein kinase activity [ISO]
- relaxation of vascular smooth muscle [IMP]
- removal of superoxide radicals [IDA, IGI, IMP, ISO, TAS]
- response to axon injury [IMP]
- response to copper ion [ISO]
- response to drug [IMP]
- response to ethanol [IMP]
- response to heat [IMP]
- response to hydrogen peroxide [IMP]
- response to nutrient levels [ISO]
- response to organic substance [ISO]
- response to oxidative stress [IDA, IMP, ISO]
- response to reactive oxygen species [IMP]
- response to superoxide [IMP, ISO]
- retina homeostasis [IMP]
- retrograde axon cargo transport [IMP]
- sensory perception of sound [IMP]
- spermatogenesis [IMP]
- superoxide anion generation [IDA]
- superoxide metabolic process [IMP, ISO]
- transmission of nerve impulse [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- cell [IMP]
- cytoplasm [ISO, TAS]
- cytoplasmic vesicle [ISO]
- cytosol [ISO]
- dendrite cytoplasm [ISO]
- dense core granule [ISO]
- extracellular matrix [ISO]
- extracellular region [ISO]
- extracellular space [IDA, ISO]
- extracellular vesicular exosome [ISO]
- intracellular [IMP]
- mitochondrial intermembrane space [ISO]
- mitochondrion [IDA, ISO]
- myelin sheath [IDA]
- neuron projection [ISO]
- neuronal cell body [ISO]
- nucleoplasm [ISO]
- nucleus [ISO]
- peroxisome [ISO]
- plasma membrane [ISO]
- protein complex [ISO]
- secretory granule [ISO]
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Molecular Chaperone Mediated Late-Stage Neuroprotection in the SOD1(G93A) Mouse Model of Amyotrophic Lateral Sclerosis.
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder characterized by the selective loss of motor neurons in the spinal cord, brain stem, and motor cortex. Mutations in superoxide dismutase (SOD1) are associated with familial ALS and lead to SOD1 protein misfolding and aggregation. Here we show that the molecular chaperone, HSJ1 (DNAJB2), mutations in which cause distal hereditary motor ... [more]
Throughput
- Low Throughput
Additional Notes
- hHSJ1a associates with SOD1 in spinal cords of DBLE transgenic male animals
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| SOD1 DNAJB2 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | 904803 |
Curated By
- BioGRID