BAIT
PRKCZ
14-3-3-zetaisoform, Pkcz, r14-3-3
protein kinase C, zeta
GO Process (43)
GO Function (10)
GO Component (21)
Gene Ontology Biological Process
- actin cytoskeleton reorganization [IMP]
- activation of phospholipase D activity [IMP]
- activation of protein kinase B activity [IMP]
- cell migration [IMP]
- cell surface receptor signaling pathway [IMP]
- cellular protein localization [IMP]
- cellular response to insulin stimulus [IMP]
- establishment of cell polarity [IMP]
- insulin receptor signaling pathway [IMP]
- intracellular signal transduction [IDA]
- long-term memory [IMP]
- long-term synaptic potentiation [IMP]
- membrane depolarization [IMP]
- membrane hyperpolarization [IMP]
- microtubule cytoskeleton organization [ISO]
- negative regulation of apoptotic process [IDA]
- negative regulation of hydrolase activity [IDA]
- negative regulation of insulin receptor signaling pathway [ISO]
- negative regulation of peptidyl-tyrosine phosphorylation [ISO]
- negative regulation of protein complex assembly [ISO]
- neuron projection extension [ISO]
- peptidyl-serine phosphorylation [IDA, ISO]
- positive regulation of ERK1 and ERK2 cascade [IMP, ISO, ISS]
- positive regulation of NF-kappaB transcription factor activity [IMP]
- positive regulation of T-helper 2 cell cytokine production [ISO, ISS]
- positive regulation of T-helper 2 cell differentiation [ISO, ISS]
- positive regulation of cell proliferation [IMP]
- positive regulation of cell-matrix adhesion [IMP]
- positive regulation of excitatory postsynaptic membrane potential [IDA]
- positive regulation of glucose import [IMP]
- positive regulation of insulin receptor signaling pathway [IMP]
- positive regulation of interleukin-10 secretion [ISO, ISS]
- positive regulation of interleukin-13 secretion [ISO, ISS]
- positive regulation of interleukin-4 production [ISO, ISS]
- positive regulation of interleukin-5 secretion [ISO, ISS]
- positive regulation of protein transport [IMP]
- positive regulation of synaptic transmission [IMP]
- protein heterooligomerization [IPI]
- protein kinase C signaling [IMP]
- protein localization to plasma membrane [ISO]
- protein phosphorylation [IDA, ISO]
- signal transduction [IDA]
- vesicle transport along microtubule [IMP]
Gene Ontology Molecular Function- 14-3-3 protein binding [IPI]
- ATP binding [IDA]
- phospholipase binding [IPI]
- potassium channel regulator activity [IMP]
- protein binding [IPI]
- protein domain specific binding [IPI]
- protein kinase C activity [IDA]
- protein kinase activity [ISO, TAS]
- protein kinase binding [IPI]
- protein serine/threonine kinase activity [IDA, ISO]
- 14-3-3 protein binding [IPI]
- ATP binding [IDA]
- phospholipase binding [IPI]
- potassium channel regulator activity [IMP]
- protein binding [IPI]
- protein domain specific binding [IPI]
- protein kinase C activity [IDA]
- protein kinase activity [ISO, TAS]
- protein kinase binding [IPI]
- protein serine/threonine kinase activity [IDA, ISO]
Gene Ontology Cellular Component
- apical cortex [ISO]
- apical plasma membrane [ISO]
- axon hillock [ISO]
- cell cortex [ISO]
- cell leading edge [IDA]
- cell-cell junction [ISO, ISS]
- cytoplasm [IDA, ISO]
- cytosol [IDA, TAS]
- extracellular vesicular exosome [ISO]
- filamentous actin [IDA]
- intracellular membrane-bounded organelle [IDA]
- membrane raft [IDA]
- microtubule organizing center [ISO]
- myelin sheath abaxonal region [ISO]
- nuclear envelope [ISO]
- nuclear matrix [ISO]
- nucleus [ISO]
- perinuclear region of cytoplasm [IDA]
- plasma membrane [IDA, ISO]
- protein complex [IDA, ISO]
- tight junction [ISO]
Rattus norvegicus
PREY
PRKCZ
14-3-3-zetaisoform, Pkcz, r14-3-3
protein kinase C, zeta
GO Process (43)
GO Function (10)
GO Component (21)
Gene Ontology Biological Process
- actin cytoskeleton reorganization [IMP]
- activation of phospholipase D activity [IMP]
- activation of protein kinase B activity [IMP]
- cell migration [IMP]
- cell surface receptor signaling pathway [IMP]
- cellular protein localization [IMP]
- cellular response to insulin stimulus [IMP]
- establishment of cell polarity [IMP]
- insulin receptor signaling pathway [IMP]
- intracellular signal transduction [IDA]
- long-term memory [IMP]
- long-term synaptic potentiation [IMP]
- membrane depolarization [IMP]
- membrane hyperpolarization [IMP]
- microtubule cytoskeleton organization [ISO]
- negative regulation of apoptotic process [IDA]
- negative regulation of hydrolase activity [IDA]
- negative regulation of insulin receptor signaling pathway [ISO]
- negative regulation of peptidyl-tyrosine phosphorylation [ISO]
- negative regulation of protein complex assembly [ISO]
- neuron projection extension [ISO]
- peptidyl-serine phosphorylation [IDA, ISO]
- positive regulation of ERK1 and ERK2 cascade [IMP, ISO, ISS]
- positive regulation of NF-kappaB transcription factor activity [IMP]
- positive regulation of T-helper 2 cell cytokine production [ISO, ISS]
- positive regulation of T-helper 2 cell differentiation [ISO, ISS]
- positive regulation of cell proliferation [IMP]
- positive regulation of cell-matrix adhesion [IMP]
- positive regulation of excitatory postsynaptic membrane potential [IDA]
- positive regulation of glucose import [IMP]
- positive regulation of insulin receptor signaling pathway [IMP]
- positive regulation of interleukin-10 secretion [ISO, ISS]
- positive regulation of interleukin-13 secretion [ISO, ISS]
- positive regulation of interleukin-4 production [ISO, ISS]
- positive regulation of interleukin-5 secretion [ISO, ISS]
- positive regulation of protein transport [IMP]
- positive regulation of synaptic transmission [IMP]
- protein heterooligomerization [IPI]
- protein kinase C signaling [IMP]
- protein localization to plasma membrane [ISO]
- protein phosphorylation [IDA, ISO]
- signal transduction [IDA]
- vesicle transport along microtubule [IMP]
Gene Ontology Molecular Function- 14-3-3 protein binding [IPI]
- ATP binding [IDA]
- phospholipase binding [IPI]
- potassium channel regulator activity [IMP]
- protein binding [IPI]
- protein domain specific binding [IPI]
- protein kinase C activity [IDA]
- protein kinase activity [ISO, TAS]
- protein kinase binding [IPI]
- protein serine/threonine kinase activity [IDA, ISO]
- 14-3-3 protein binding [IPI]
- ATP binding [IDA]
- phospholipase binding [IPI]
- potassium channel regulator activity [IMP]
- protein binding [IPI]
- protein domain specific binding [IPI]
- protein kinase C activity [IDA]
- protein kinase activity [ISO, TAS]
- protein kinase binding [IPI]
- protein serine/threonine kinase activity [IDA, ISO]
Gene Ontology Cellular Component
- apical cortex [ISO]
- apical plasma membrane [ISO]
- axon hillock [ISO]
- cell cortex [ISO]
- cell leading edge [IDA]
- cell-cell junction [ISO, ISS]
- cytoplasm [IDA, ISO]
- cytosol [IDA, TAS]
- extracellular vesicular exosome [ISO]
- filamentous actin [IDA]
- intracellular membrane-bounded organelle [IDA]
- membrane raft [IDA]
- microtubule organizing center [ISO]
- myelin sheath abaxonal region [ISO]
- nuclear envelope [ISO]
- nuclear matrix [ISO]
- nucleus [ISO]
- perinuclear region of cytoplasm [IDA]
- plasma membrane [IDA, ISO]
- protein complex [IDA, ISO]
- tight junction [ISO]
Rattus norvegicus
Biochemical Activity (Phosphorylation)
An interaction is inferred from the biochemical effect of one protein upon another, for example, GTP-GDP exchange activity or phosphorylation of a substrate by a kinase. The bait protein executes the activity on the substrate hit protein. A Modification value is recorded for interactions of this type with the possible values Phosphorylation, Ubiquitination, Sumoylation, Dephosphorylation, Methylation, Prenylation, Acetylation, Deubiquitination, Proteolytic Processing, Glucosylation, Nedd(Rub1)ylation, Deacetylation, No Modification, Demethylation.
Publication
Glucose activates protein kinase C-zeta /lambda through proline-rich tyrosine kinase-2, extracellular signal-regulated kinase, and phospholipase D: a novel mechanism for activating glucose transporter translocation.
Insulin controls glucose uptake by translocating GLUT4 and other glucose transporters to the plasma membrane in muscle and adipose tissues by a mechanism that appears to require protein kinase C (PKC)-zeta/lambda operating downstream of phosphatidylinositol 3-kinase. In diabetes mellitus, insulin-stimulated glucose uptake is diminished, but with hyperglycemia, uptake is maintained but by uncertain mechanisms. Presently, we found that glucose acutely ... [more]
J. Biol. Chem. Sep. 21, 2001; 276(38);35537-45 [Pubmed: 11463795]
Throughput
- Low Throughput
Curated By
- BioGRID