PRKCI
Gene Ontology Biological Process
- Golgi vesicle budding [IDA]
- actin filament organization [ISO]
- cell migration [IMP]
- cell-cell junction organization [ISO]
- cellular protein localization [IMP]
- cellular response to insulin stimulus [IMP, ISO]
- establishment of apical/basal cell polarity [ISO]
- eye photoreceptor cell development [ISO]
- negative regulation of glial cell apoptotic process [ISO, ISS]
- negative regulation of neuron apoptotic process [ISO, ISS]
- positive regulation of NF-kappaB transcription factor activity [ISO, ISS]
- positive regulation of endothelial cell apoptotic process [ISO, ISS]
- positive regulation of establishment of protein localization to plasma membrane [ISO]
- positive regulation of glial cell proliferation [ISO, ISS]
- positive regulation of glucose import [ISO]
- positive regulation of neuron projection development [ISO, ISS]
- protein phosphorylation [IDA, ISO]
- response to interleukin-1 [IMP]
- response to peptide hormone [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- Golgi membrane [IDA]
- Schmidt-Lanterman incisure [ISO]
- apical part of cell [ISO]
- apical plasma membrane [ISO]
- cell leading edge [IDA]
- cytoplasm [ISO]
- cytosol [IDA, ISO, ISS]
- extracellular vesicular exosome [ISO]
- intercellular bridge [ISO]
- microtubule cytoskeleton [ISO]
- nucleus [ISO, ISS]
- plasma membrane [IDA]
- protein complex [IDA]
- tight junction [IDA]
PRKCI
Gene Ontology Biological Process
- Golgi vesicle budding [IDA]
- actin filament organization [ISO]
- cell migration [IMP]
- cell-cell junction organization [ISO]
- cellular protein localization [IMP]
- cellular response to insulin stimulus [IMP, ISO]
- establishment of apical/basal cell polarity [ISO]
- eye photoreceptor cell development [ISO]
- negative regulation of glial cell apoptotic process [ISO, ISS]
- negative regulation of neuron apoptotic process [ISO, ISS]
- positive regulation of NF-kappaB transcription factor activity [ISO, ISS]
- positive regulation of endothelial cell apoptotic process [ISO, ISS]
- positive regulation of establishment of protein localization to plasma membrane [ISO]
- positive regulation of glial cell proliferation [ISO, ISS]
- positive regulation of glucose import [ISO]
- positive regulation of neuron projection development [ISO, ISS]
- protein phosphorylation [IDA, ISO]
- response to interleukin-1 [IMP]
- response to peptide hormone [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- Golgi membrane [IDA]
- Schmidt-Lanterman incisure [ISO]
- apical part of cell [ISO]
- apical plasma membrane [ISO]
- cell leading edge [IDA]
- cytoplasm [ISO]
- cytosol [IDA, ISO, ISS]
- extracellular vesicular exosome [ISO]
- intercellular bridge [ISO]
- microtubule cytoskeleton [ISO]
- nucleus [ISO, ISS]
- plasma membrane [IDA]
- protein complex [IDA]
- tight junction [IDA]
Biochemical Activity (Phosphorylation)
An interaction is inferred from the biochemical effect of one protein upon another, for example, GTP-GDP exchange activity or phosphorylation of a substrate by a kinase. The bait protein executes the activity on the substrate hit protein. A Modification value is recorded for interactions of this type with the possible values Phosphorylation, Ubiquitination, Sumoylation, Dephosphorylation, Methylation, Prenylation, Acetylation, Deubiquitination, Proteolytic Processing, Glucosylation, Nedd(Rub1)ylation, Deacetylation, No Modification, Demethylation.
Publication
Glucose activates protein kinase C-zeta /lambda through proline-rich tyrosine kinase-2, extracellular signal-regulated kinase, and phospholipase D: a novel mechanism for activating glucose transporter translocation.
Insulin controls glucose uptake by translocating GLUT4 and other glucose transporters to the plasma membrane in muscle and adipose tissues by a mechanism that appears to require protein kinase C (PKC)-zeta/lambda operating downstream of phosphatidylinositol 3-kinase. In diabetes mellitus, insulin-stimulated glucose uptake is diminished, but with hyperglycemia, uptake is maintained but by uncertain mechanisms. Presently, we found that glucose acutely ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID