Synthetic Lethality

A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.


The formins Cdc12 and For3 cooperate during contractile ring assembly in cytokinesis.

Coffman VC, Sees JA, Kovar DR, Wu JQ

Both de novo-assembled actin filaments at the division site and existing filaments recruited by directional cortical transport contribute to contractile ring formation during cytokinesis. However, it is unknown which source is more important. Here, we show that fission yeast formin For3 is responsible for node condensation into clumps in the absence of formin Cdc12. For3 localization at the division site ... [more]

J. Cell Biol. Oct. 14, 2013; 203(1);101-14 [Pubmed: 24127216]


  • Low Throughput

Ontology Terms

  • phenotype: inviable (APO:0000112)

Curated By

  • BioGRID