CDC12
Gene Ontology Biological Process
- actin crosslink formation [IMP]
- actin filament organization [IMP]
- actin filament polymerization [IDA, IMP]
- actin nucleation [TAS]
- actomyosin contractile ring actin filament bundle assembly [NAS]
- mitotic actomyosin contractile ring assembly [IMP]
- mitotic actomyosin contractile ring maintenance [IMP]
- protein localization to actin cytoskeleton [IMP]
- regulation of actin filament polymerization [IMP]
- transitional endoplasmic reticulum polarization at cell division site [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
FOR3
Gene Ontology Biological Process
- actin filament bundle assembly [IMP]
- actin filament organization [IMP]
- actin nucleation [ISM]
- activation of bipolar cell growth [IMP]
- establishment or maintenance of cell polarity regulating cell shape [IMP]
- microtubule cytoskeleton organization [IGI]
- mitotic actomyosin contractile ring assembly [IGI]
- protein localization to actin cytoskeleton [IMP]
- regulation of filamentous growth [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Synthetic Lethality
A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.
Publication
The formins Cdc12 and For3 cooperate during contractile ring assembly in cytokinesis.
Both de novo-assembled actin filaments at the division site and existing filaments recruited by directional cortical transport contribute to contractile ring formation during cytokinesis. However, it is unknown which source is more important. Here, we show that fission yeast formin For3 is responsible for node condensation into clumps in the absence of formin Cdc12. For3 localization at the division site ... [more]
Throughput
- Low Throughput
Ontology Terms
- phenotype: inviable (APO:0000112)
- phenotype: cytokinesis (APO:0000071)
Additional Notes
- delta503-cdc12/for3null and delta841-cdc12/for3null mutants are lethal with evidence of cytokinesis defects
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| CDC12 FOR3 | Phenotypic Enhancement Phenotypic Enhancement A genetic interaction is inferred when mutation or overexpression of one gene results in enhancement of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene. | Low | - | BioGRID | 905070 | |
| CDC12 FOR3 | Phenotypic Enhancement Phenotypic Enhancement A genetic interaction is inferred when mutation or overexpression of one gene results in enhancement of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene. | Low | - | BioGRID | 736296 |
Curated By
- BioGRID