CDC12
Gene Ontology Biological Process
- actin crosslink formation [IMP]
- actin filament organization [IMP]
- actin filament polymerization [IDA, IMP]
- actin nucleation [TAS]
- actomyosin contractile ring actin filament bundle assembly [NAS]
- mitotic actomyosin contractile ring assembly [IMP]
- mitotic actomyosin contractile ring maintenance [IMP]
- protein localization to actin cytoskeleton [IMP]
- regulation of actin filament polymerization [IMP]
- transitional endoplasmic reticulum polarization at cell division site [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
MYO2
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Synthetic Lethality
A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.
Publication
The formins Cdc12 and For3 cooperate during contractile ring assembly in cytokinesis.
Both de novo-assembled actin filaments at the division site and existing filaments recruited by directional cortical transport contribute to contractile ring formation during cytokinesis. However, it is unknown which source is more important. Here, we show that fission yeast formin For3 is responsible for node condensation into clumps in the absence of formin Cdc12. For3 localization at the division site ... [more]
Throughput
- Low Throughput
Ontology Terms
- phenotype: inviable (APO:0000112)
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| CDC12 MYO2 | Synthetic Growth Defect Synthetic Growth Defect A genetic interaction is inferred when mutations in separate genes, each of which alone causes a minimal phenotype, result in a significant growth defect under a given condition when combined in the same cell. | Low | - | BioGRID | 905058 | |
| MYO2 CDC12 | Synthetic Lethality Synthetic Lethality A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition. | Low | - | PomBase | - | |
| CDC12 MYO2 | Synthetic Lethality Synthetic Lethality A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition. | Low | - | PomBase | - |
Curated By
- BioGRID