RQCD1
Gene Ontology Biological Process
- RNA metabolic process [TAS]
- gene expression [TAS]
- mRNA metabolic process [TAS]
- negative regulation of intracellular estrogen receptor signaling pathway [IMP]
- nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [TAS]
- nuclear-transcribed mRNA poly(A) tail shortening [TAS]
- positive regulation of ligand-dependent nuclear receptor transcription coactivator activity [IDA]
- sex differentiation [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
GRB10
Gene Ontology Biological Process
- insulin receptor signaling pathway [ISS, TAS]
- negative regulation of Wnt signaling pathway [IDA]
- negative regulation of glucose import [ISS]
- negative regulation of glycogen biosynthetic process [ISS]
- negative regulation of insulin receptor signaling pathway [ISS]
- positive regulation of phosphorylation [ISS]
- positive regulation of vascular endothelial growth factor receptor signaling pathway [IDA]
- response to insulin [ISS]
Gene Ontology Molecular Function
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Critical involvement of RQCD1 in the EGFR-Akt pathway in mammary carcinogenesis.
We previously reported an important role of RQCD1 in mammary carcinogenesis through the interaction with Grb10 interacting GYF protein 1 (GIGYF1), Grb10 interacting GYF protein 2 (GIGYF2) and growth factor receptor binding protein 10 (Grb10). In this study, we investigated the biological mechanism of RQCD1 in regulation of the Akt activity as the downstream signal of epidermal growth factor receptor ... [more]
Throughput
- Low Throughput
Ontology Terms
- cell line: hela cell (BTO:0000567)
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| RQCD1 GRB10 | Reconstituted Complex Reconstituted Complex An interaction is detected between purified proteins in vitro. | Low | - | BioGRID | - |
Curated By
- BioGRID