LEP
Gene Ontology Biological Process
- JAK-STAT cascade [TAS]
- adipose tissue development [ISO]
- adult feeding behavior [ISO, ISS]
- bile acid metabolic process [ISO]
- bone mineralization involved in bone maturation [IDA]
- cAMP-mediated signaling [TAS]
- cardiac muscle hypertrophy [IDA]
- cellular response to L-ascorbic acid [IEP]
- cellular response to retinoic acid [IEP]
- central nervous system neuron development [ISO]
- cholesterol metabolic process [ISO]
- circadian rhythm [IEP]
- eating behavior [ISO]
- energy reserve metabolic process [IDA]
- fatty acid beta-oxidation [ISO]
- fatty acid catabolic process [IDA]
- female pregnancy [IEP]
- glucose homeostasis [ISO]
- glucose metabolic process [ISO]
- glycerol biosynthetic process [IDA]
- hormone metabolic process [ISO]
- insulin secretion [ISO]
- intracellular signal transduction [IDA, TAS]
- leptin-mediated signaling pathway [IDA]
- leukocyte tethering or rolling [IDA]
- lipid metabolic process [ISO]
- negative regulation of apoptotic process [IDA]
- negative regulation of appetite [ISO, ISS]
- negative regulation of cartilage development [IDA]
- negative regulation of glucagon secretion [ISO]
- negative regulation of glutamine transport [IMP]
- negative regulation of metabolic process [IDA]
- negative regulation of transcription from RNA polymerase II promoter [ISO]
- negative regulation of vasoconstriction [IDA]
- ovulation from ovarian follicle [IDA]
- placenta development [ISO]
- positive regulation of JAK-STAT cascade [IMP, ISO]
- positive regulation of MAPK cascade [IDA]
- positive regulation of STAT protein import into nucleus [ISO]
- positive regulation of cell proliferation [IDA]
- positive regulation of cytokine production [IEP]
- positive regulation of developmental growth [ISO]
- positive regulation of follicle-stimulating hormone secretion [IEP]
- positive regulation of hepatic stellate cell activation [IDA]
- positive regulation of insulin receptor signaling pathway [IDA]
- positive regulation of ion transport [IDA]
- positive regulation of luteinizing hormone secretion [IEP]
- positive regulation of myeloid cell differentiation [ISO]
- positive regulation of peroxisome proliferator activated receptor signaling pathway [IDA]
- positive regulation of protein import into nucleus [ISO]
- positive regulation of reactive oxygen species metabolic process [IDA]
- positive regulation of tyrosine phosphorylation of Stat3 protein [IMP]
- regulation of blood pressure [IDA]
- regulation of fat cell differentiation [ISO]
- regulation of gluconeogenesis [ISO]
- regulation of insulin secretion [ISO]
- regulation of intestinal cholesterol absorption [ISO]
- regulation of lipoprotein lipid oxidation [IDA]
- regulation of metabolic process [ISO]
- regulation of protein localization to nucleus [ISO]
- regulation of protein phosphorylation [ISO]
- regulation of steroid biosynthetic process [ISO]
- response to dietary excess [IMP, ISO]
- response to hypoxia [IEP]
- response to insulin [ISO]
- response to nutrient [IEP]
- response to vitamin E [IEP]
- tyrosine phosphorylation of STAT protein [ISO]
Gene Ontology Molecular Function
ZBTB17
Gene Ontology Biological Process
Gene Ontology Molecular Function
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Interaction of insulin-like growth factor binding protein-4, Miz-1, leptin, lipocalin-type prostaglandin D synthase, and granulin precursor with the N-terminal half of type III hexokinase.
Insulin-like growth factor binding protein-4, Miz-1, leptin, prostaglandin D synthase, and granulin precursor were identified as proteins interacting with the N-terminal half of mammalian Type III hexokinase (HKIII) in the yeast two-hybrid method. These interactions were confirmed by in vitro binding studies. All five of these proteins, and their mRNAs, were present in PC12 cells, as shown by immunoblotting and ... [more]
Throughput
- Low Throughput
Additional Notes
- interaction occurred between endogenous proteins in rat PC12 cells
Curated By
- BioGRID