MDM2
Gene Ontology Biological Process
- DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest [IMP, TAS]
- Fc-epsilon receptor signaling pathway [TAS]
- cellular response to hypoxia [IEP]
- epidermal growth factor receptor signaling pathway [TAS]
- establishment of protein localization [IDA]
- fibroblast growth factor receptor signaling pathway [TAS]
- innate immune response [TAS]
- negative regulation of DNA damage response, signal transduction by p53 class mediator [IDA]
- negative regulation of cell cycle arrest [IDA]
- negative regulation of transcription from RNA polymerase II promoter [IDA]
- negative regulation of transcription, DNA-templated [IDA]
- neurotrophin TRK receptor signaling pathway [TAS]
- peptidyl-lysine modification [IMP]
- phosphatidylinositol-mediated signaling [TAS]
- positive regulation of cell proliferation [TAS]
- positive regulation of mitotic cell cycle [IMP]
- positive regulation of proteasomal ubiquitin-dependent protein catabolic process [IDA]
- protein complex assembly [IDA]
- protein destabilization [IDA]
- protein localization to nucleus [IDA]
- protein ubiquitination [IDA]
- protein ubiquitination involved in ubiquitin-dependent protein catabolic process [IDA]
- regulation of protein catabolic process [IDA]
- response to antibiotic [IEP]
- synaptic transmission [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
RYR2
Gene Ontology Biological Process
- Purkinje myocyte to ventricular cardiac muscle cell signaling [ISS]
- calcium ion transport [IDA]
- calcium ion transport into cytosol [IDA]
- calcium-mediated signaling [ISS]
- calcium-mediated signaling using intracellular calcium source [IDA]
- cardiac muscle contraction [IMP]
- cardiac muscle hypertrophy [ISS]
- cell communication by electrical coupling involved in cardiac conduction [IC]
- cellular calcium ion homeostasis [ISS]
- cellular response to caffeine [IDA, ISS]
- cellular response to epinephrine stimulus [TAS]
- cytosolic calcium ion homeostasis [ISS]
- detection of calcium ion [IDA]
- embryonic heart tube morphogenesis [ISS]
- establishment of protein localization to endoplasmic reticulum [IDA]
- ion transmembrane transport [TAS]
- left ventricular cardiac muscle tissue morphogenesis [ISS]
- positive regulation of calcium-transporting ATPase activity [IDA]
- positive regulation of heart rate [ISS]
- positive regulation of ryanodine-sensitive calcium-release channel activity by adrenergic receptor signaling pathway involved in positive regulation of cardiac muscle contraction [ISS]
- positive regulation of sequestering of calcium ion [IDA]
- positive regulation of the force of heart contraction [IMP]
- regulation of cardiac muscle contraction [IMP]
- regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion [IC, ISS]
- regulation of heart rate [IMP]
- release of sequestered calcium ion into cytosol [IDA, ISS]
- release of sequestered calcium ion into cytosol by sarcoplasmic reticulum [IMP, ISS]
- response to caffeine [IDA]
- response to hypoxia [ISS]
- response to muscle stretch [IMP]
- response to redox state [IDA]
- sarcoplasmic reticulum calcium ion transport [TAS]
- transmembrane transport [TAS]
- type B pancreatic cell apoptotic process [IMP]
- ventricular cardiac muscle cell action potential [ISS]
Gene Ontology Molecular Function- calcium channel activity [ISS]
- calcium-induced calcium release activity [IDA]
- calcium-release channel activity [IDA]
- calmodulin binding [IMP, IPI, ISS]
- enzyme binding [IPI]
- identical protein binding [IPI]
- intracellular ligand-gated calcium channel activity [ISS]
- ion channel binding [ISS]
- protein binding [IPI]
- protein kinase A catalytic subunit binding [IDA]
- protein kinase A regulatory subunit binding [IDA]
- ryanodine-sensitive calcium-release channel activity [IDA]
- suramin binding [IMP]
- calcium channel activity [ISS]
- calcium-induced calcium release activity [IDA]
- calcium-release channel activity [IDA]
- calmodulin binding [IMP, IPI, ISS]
- enzyme binding [IPI]
- identical protein binding [IPI]
- intracellular ligand-gated calcium channel activity [ISS]
- ion channel binding [ISS]
- protein binding [IPI]
- protein kinase A catalytic subunit binding [IDA]
- protein kinase A regulatory subunit binding [IDA]
- ryanodine-sensitive calcium-release channel activity [IDA]
- suramin binding [IMP]
Gene Ontology Cellular Component
Reconstituted Complex
An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator.
Publication
A comprehensive resource of interacting protein regions for refining human transcription factor networks.
Large-scale data sets of protein-protein interactions (PPIs) are a valuable resource for mapping and analysis of the topological and dynamic features of interactome networks. The currently available large-scale PPI data sets only contain information on interaction partners. The data presented in this study also include the sequences involved in the interactions (i.e., the interacting regions, IRs) suggested to correspond to ... [more]
Throughput
- High Throughput|Low Throughput
Additional Notes
- Interaction from HTP screen was verified by pull-downs from in vitro translated proteins
- Protein-protein interactions detected between proteins translated in vitro
Curated By
- BioGRID