TERT
Gene Ontology Biological Process
- DNA strand elongation [IDA]
- age-dependent telomere shortening [IBA]
- mitochondrion organization [IDA]
- negative regulation of extrinsic apoptotic signaling pathway in absence of ligand [IMP]
- positive regulation of Wnt signaling pathway [IGI]
- replicative senescence [IMP]
- telomere formation via telomerase [IDA]
- telomere maintenance [TAS]
- telomere maintenance via telomerase [IMP, NAS, TAS]
Gene Ontology Molecular Function- DNA binding [IDA]
- RNA-directed DNA polymerase activity [IDA]
- protein binding [IPI]
- protein homodimerization activity [IDA]
- tRNA binding [IDA]
- telomerase activity [IDA]
- telomeric DNA binding [TAS]
- telomeric RNA binding [IDA]
- telomeric template RNA reverse transcriptase activity [IDA, TAS]
- transcription coactivator binding [IPI]
- DNA binding [IDA]
- RNA-directed DNA polymerase activity [IDA]
- protein binding [IPI]
- protein homodimerization activity [IDA]
- tRNA binding [IDA]
- telomerase activity [IDA]
- telomeric DNA binding [TAS]
- telomeric RNA binding [IDA]
- telomeric template RNA reverse transcriptase activity [IDA, TAS]
- transcription coactivator binding [IPI]
Gene Ontology Cellular Component
HSPA4
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Reconstituted Complex
An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator.
Publication
Stable association of hsp90 and p23, but Not hsp70, with active human telomerase.
The ribonucleoprotein telomerase holoenzyme is minimally composed of a catalytic subunit, hTERT, and its associated template RNA component, hTR. We have previously found two additional components of the telomerase holoenzyme, the chaperones p23 and heat shock protein (hsp) 90, both of which are required for efficient telomerase assembly in vitro and in vivo. Both hsp90 and p23 bind specifically to ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID