SHC1
Gene Ontology Biological Process
- MAPK cascade [ISO]
- actin cytoskeleton organization [IMP]
- actin cytoskeleton reorganization [ISO]
- activation of MAPK activity [IMP, ISO]
- aging [IPI]
- angiogenesis [ISO]
- cellular response to insulin stimulus [IEP]
- epidermal growth factor receptor signaling pathway [IBA, ISO]
- heart development [ISO]
- insulin receptor signaling pathway [IDA, IMP]
- neuron differentiation [IMP]
- neuron projection development [IMP]
- organ regeneration [IEP]
- positive regulation of DNA replication [IMP]
- positive regulation of smooth muscle cell proliferation [IMP]
- positive regulation of vasoconstriction [IMP]
- regulation of cell proliferation [ISO]
- response to glucocorticoid [IEP]
- response to hydrogen peroxide [IEP]
- response to hypoxia [IEP]
- response to insulin [IEP]
- response to nicotine [IEP]
- response to organic cyclic compound [IEP]
- response to toxic substance [IEP]
- single organismal cell-cell adhesion [ISO]
Gene Ontology Molecular Function- ephrin receptor binding [ISO]
- epidermal growth factor receptor binding [IPI]
- insulin receptor binding [ISO]
- insulin-like growth factor receptor binding [ISO]
- neurotrophin TRKA receptor binding [ISO]
- phosphoprotein binding [IPI]
- phosphotyrosine binding [IPI]
- protein binding [IPI]
- protein complex binding [IPI]
- protein kinase binding [IBA]
- protein phosphatase 2A binding [IDA, IPI]
- receptor tyrosine kinase binding [IPI, ISO]
- ephrin receptor binding [ISO]
- epidermal growth factor receptor binding [IPI]
- insulin receptor binding [ISO]
- insulin-like growth factor receptor binding [ISO]
- neurotrophin TRKA receptor binding [ISO]
- phosphoprotein binding [IPI]
- phosphotyrosine binding [IPI]
- protein binding [IPI]
- protein complex binding [IPI]
- protein kinase binding [IBA]
- protein phosphatase 2A binding [IDA, IPI]
- receptor tyrosine kinase binding [IPI, ISO]
Gene Ontology Cellular Component
INPP5D
Gene Ontology Biological Process
- determination of adult lifespan [ISO]
- immunoglobulin mediated immune response [ISO]
- intracellular signal transduction [ISO]
- negative regulation of B cell activation [ISO]
- negative regulation of B cell proliferation [ISO]
- negative regulation of bone resorption [ISO]
- negative regulation of cell proliferation [ISO]
- negative regulation of granulocyte differentiation [ISO]
- negative regulation of immune response [ISO]
- negative regulation of interleukin-6 biosynthetic process [ISO]
- negative regulation of monocyte differentiation [ISO]
- negative regulation of neutrophil differentiation [ISO]
- negative regulation of osteoclast differentiation [ISO]
- negative regulation of signal transduction [ISO]
- positive regulation of B cell differentiation [ISO]
- positive regulation of apoptotic process [ISO]
- positive regulation of erythrocyte differentiation [ISO]
- positive regulation of lymphocyte differentiation [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Downstream of kinase, p62(dok), is a mediator of Fc gamma IIB inhibition of Fc epsilon RI signaling.
The low-affinity receptor for IgG, Fc gamma RIIB, is expressed widely in the immune system and functions to attenuate Ag-induced immune responses. In mast cells, coaggregation of Fc gamma RIIB with the high-affinity IgE receptor, Fc epsilon RI, leads to inhibition of Ag-induced degranulation and cytokine production. Fc gamma RIIB inhibitory activity requires a conserved motif within the Fc gamma ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| SHC1 INPP5D | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - |
Curated By
- BioGRID