SRPK2
Gene Ontology Biological Process
- RNA splicing [IDA]
- angiogenesis [ISS]
- innate immune response [IC]
- intracellular signal transduction [IDA]
- negative regulation of viral genome replication [IDA]
- nuclear speck organization [ISS]
- positive regulation of cell cycle [ISS]
- positive regulation of cell proliferation [IDA]
- positive regulation of gene expression [ISS]
- positive regulation of neuron apoptotic process [ISS]
- positive regulation of viral genome replication [IDA]
- protein phosphorylation [IDA]
- regulation of mRNA splicing, via spliceosome [TAS]
- spliceosomal complex assembly [IDA]
Gene Ontology Molecular Function
ERN1
Gene Ontology Biological Process
- HAC1-type intron splice site recognition and cleavage [IDA]
- RNA phosphodiester bond hydrolysis, endonucleolytic [IDA, TAS]
- RNA splicing [IMP]
- activation of signaling protein activity involved in unfolded protein response [IDA, TAS]
- cell cycle arrest [ISS]
- cellular protein metabolic process [TAS]
- cellular response to vascular endothelial growth factor stimulus [IDA]
- endoplasmic reticulum unfolded protein response [TAS]
- endothelial cell proliferation [IDA]
- mRNA cleavage [IDA]
- mRNA splicing, via endonucleolytic cleavage and ligation [IDA]
- peptidyl-serine autophosphorylation [IDA]
- positive regulation of RNA splicing [IDA]
- positive regulation of endoplasmic reticulum unfolded protein response [IMP]
- protein phosphorylation [IDA]
- protein trans-autophosphorylation [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Biochemical Activity (Phosphorylation)
An interaction is inferred from the biochemical effect of one protein upon another, for example, GTP-GDP exchange activity or phosphorylation of a substrate by a kinase. The bait protein executes the activity on the substrate hit protein. A Modification value is recorded for interactions of this type with the possible values Phosphorylation, Ubiquitination, Sumoylation, Dephosphorylation, Methylation, Prenylation, Acetylation, Deubiquitination, Proteolytic Processing, Glucosylation, Nedd(Rub1)ylation, Deacetylation, No Modification, Demethylation.
Publication
The protein interaction landscape of the human CMGC kinase group.
Cellular information processing via reversible protein phosphorylation requires tight control of the localization, activity, and substrate specificity of protein kinases, which to a large extent is accomplished by complex formation with other proteins. Despite their critical role in cellular regulation and pathogenesis, protein interaction information is available for only a subset of the 518 human protein kinases. Here we present ... [more]
Throughput
- High Throughput
Additional Notes
- Substrate (Hit) was protein microarray; all hits had Z-score greater than 0.25
Curated By
- BioGRID