SRPK1
Gene Ontology Biological Process
- chromosome segregation [IDA]
- innate immune response [IC]
- intracellular signal transduction [IDA]
- negative regulation of viral genome replication [IDA]
- positive regulation of viral genome replication [IDA]
- protein phosphorylation [IDA]
- regulation of mRNA processing [IDA]
- regulation of mRNA splicing, via spliceosome [TAS]
- sperm chromatin condensation [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
FLT1
Gene Ontology Biological Process
- blood vessel morphogenesis [ISS]
- cell migration [IMP]
- cellular response to vascular endothelial growth factor stimulus [IDA]
- embryonic morphogenesis [ISS]
- monocyte chemotaxis [IDA]
- peptidyl-tyrosine phosphorylation [IDA]
- positive regulation of MAP kinase activity [IDA]
- positive regulation of MAPK cascade [IDA]
- positive regulation of angiogenesis [IMP]
- positive regulation of cell migration [IDA]
- positive regulation of cell proliferation [TAS]
- positive regulation of phosphatidylinositol 3-kinase activity [IMP]
- positive regulation of phosphatidylinositol 3-kinase signaling [IMP]
- positive regulation of phospholipase C activity [IMP]
- positive regulation of vascular endothelial growth factor receptor signaling pathway [IDA]
- protein autophosphorylation [IDA]
- transmembrane receptor protein tyrosine kinase signaling pathway [TAS]
- vascular endothelial growth factor receptor signaling pathway [IDA, IMP, TAS]
- vascular endothelial growth factor receptor-1 signaling pathway [IDA]
- vascular endothelial growth factor signaling pathway [IDA, IMP, TAS]
Gene Ontology Molecular Function- VEGF-A-activated receptor activity [IDA]
- VEGF-B-activated receptor activity [IDA]
- growth factor binding [IPI]
- placental growth factor-activated receptor activity [IDA]
- protein binding [IPI]
- transmembrane receptor protein tyrosine kinase activity [TAS]
- vascular endothelial growth factor-activated receptor activity [IDA, IMP]
- VEGF-A-activated receptor activity [IDA]
- VEGF-B-activated receptor activity [IDA]
- growth factor binding [IPI]
- placental growth factor-activated receptor activity [IDA]
- protein binding [IPI]
- transmembrane receptor protein tyrosine kinase activity [TAS]
- vascular endothelial growth factor-activated receptor activity [IDA, IMP]
Gene Ontology Cellular Component
Biochemical Activity (Phosphorylation)
An interaction is inferred from the biochemical effect of one protein upon another, for example, GTP-GDP exchange activity or phosphorylation of a substrate by a kinase. The bait protein executes the activity on the substrate hit protein. A Modification value is recorded for interactions of this type with the possible values Phosphorylation, Ubiquitination, Sumoylation, Dephosphorylation, Methylation, Prenylation, Acetylation, Deubiquitination, Proteolytic Processing, Glucosylation, Nedd(Rub1)ylation, Deacetylation, No Modification, Demethylation.
Publication
The protein interaction landscape of the human CMGC kinase group.
Cellular information processing via reversible protein phosphorylation requires tight control of the localization, activity, and substrate specificity of protein kinases, which to a large extent is accomplished by complex formation with other proteins. Despite their critical role in cellular regulation and pathogenesis, protein interaction information is available for only a subset of the 518 human protein kinases. Here we present ... [more]
Throughput
- High Throughput
Additional Notes
- Substrate (Hit) was protein microarray; all hits had Z-score greater than 0.25
Curated By
- BioGRID