BAIT
ELAVL1
HuR
ELAV like RNA binding protein 1
GO Process (4)
GO Function (7)
GO Component (3)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Rattus norvegicus
PREY
SERPINE1
PAI1A, Pai1, Pai1aa, Planh, RATPAI1A
serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
GO Process (72)
GO Function (3)
GO Component (5)
Gene Ontology Biological Process
- angiogenesis [ISO]
- cellular response to ATP [IEP]
- cellular response to cAMP [IEP]
- cellular response to cGMP [IEP]
- cellular response to cycloheximide [IEP]
- cellular response to dexamethasone stimulus [IEP]
- cellular response to drug [IDA]
- cellular response to fibroblast growth factor stimulus [IEP]
- cellular response to follicle-stimulating hormone stimulus [IEP]
- cellular response to glucagon stimulus [IEP]
- cellular response to glucose stimulus [IEP]
- cellular response to gravity [IEP]
- cellular response to growth factor stimulus [IEP]
- cellular response to hydrogen peroxide [IEP]
- cellular response to hypoxia [IEP]
- cellular response to insulin stimulus [IEP]
- cellular response to interleukin-1 [IDA]
- cellular response to lipopolysaccharide [ISO]
- cellular response to low-density lipoprotein particle stimulus [IEP]
- cellular response to mechanical stimulus [IEP]
- cellular response to metal ion [IEP]
- cellular response to nerve growth factor stimulus [IEP]
- cellular response to nicotine [IEP]
- cellular response to organic cyclic compound [IEP]
- cellular response to platelet-derived growth factor stimulus [IEP]
- cellular response to potassium ion [IEP]
- cellular response to transforming growth factor beta stimulus [IEP, ISO]
- chronological cell aging [ISO]
- decidualization [IEP]
- defense response to Gram-negative bacterium [ISO]
- female gonad development [IDA]
- glucose homeostasis [IEP]
- mast cell activation [IEP]
- negative regulation of cell adhesion mediated by integrin [ISO]
- negative regulation of cell migration [IDA, IMP, ISO]
- negative regulation of endopeptidase activity [IBA, IC, IDA, ISO]
- negative regulation of endothelial cell apoptotic process [ISO]
- negative regulation of extrinsic apoptotic signaling pathway via death domain receptors [ISO]
- negative regulation of fibrinolysis [ISO]
- negative regulation of gene expression [IMP]
- negative regulation of plasminogen activation [ISO]
- negative regulation of proteolysis [TAS]
- negative regulation of smooth muscle cell migration [ISO]
- negative regulation of smooth muscle cell-matrix adhesion [ISO]
- negative regulation of vascular wound healing [ISO]
- positive regulation of angiogenesis [ISO]
- positive regulation of blood coagulation [ISO]
- positive regulation of calcium ion import [IMP]
- positive regulation of coagulation [IMP]
- positive regulation of fibroblast proliferation [IMP]
- positive regulation of gene expression [IMP]
- positive regulation of inflammatory response [ISO]
- positive regulation of interleukin-8 production [ISO]
- positive regulation of keratinocyte migration [IMP]
- positive regulation of leukotriene production involved in inflammatory response [ISO]
- positive regulation of monocyte chemotaxis [ISO]
- positive regulation of receptor-mediated endocytosis [IMP, ISO]
- regulation of angiogenesis [ISO]
- regulation of cell proliferation [ISO]
- regulation of proteolysis [IBA]
- regulation of receptor activity [ISO]
- response to cytokine [IEP]
- response to epidermal growth factor [IEP]
- response to estrogen [IEP]
- response to hyperoxia [IEP]
- response to laminar fluid shear stress [IEP]
- response to lipopolysaccharide [IEP]
- response to reactive oxygen species [IEP]
- response to starvation [IEP]
- response to transforming growth factor beta [IEP]
- tissue regeneration [IEP]
- wound healing [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Rattus norvegicus
Affinity Capture-RNA
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and associated RNA species identified by Northern blot, RT-PCR, affinity labeling, sequencing, or microarray analysis.
Publication
Angiotensin II induces renal plasminogen activator inhibitor-1 and cyclooxygenase-2 expression post-transcriptionally via activation of the mRNA-stabilizing factor human-antigen R.
Angiotensin (Ang) II-induced fibrosis of the kidney is characterized by the enhanced expression of profibrotic and proinflammatory genes, including the serine protease inhibitor plasminogen activator inhibitor-1 (PAI-1) and cyclooxygenase-2 (COX-2). In addition to transcriptional regulation, both genes are subject to post-transcriptional control by AU-rich destabilizing elements that reside within the 3' untranslated region of the mRNA. We demonstrated that the ... [more]
Am. J. Pathol. Apr. 01, 2009; 174(4);1252-63 [Pubmed: 19246637]
Throughput
- Low Throughput
Ontology Terms
- chemical: angiotensin ii (CHEBI:48432)
Additional Notes
- angiotensin II (CHEBI:48432) increases binding
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| ELAVL1 SERPINE1 | Protein-RNA Protein-RNA An interaction is detected between and protein and an RNA in vitro. | Low | - | BioGRID | 907686 |
Curated By
- BioGRID