BAIT
SERPINE1
PAI1A, Pai1, Pai1aa, Planh, RATPAI1A
serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
GO Process (72)
GO Function (3)
GO Component (5)
Gene Ontology Biological Process
- angiogenesis [ISO]
- cellular response to ATP [IEP]
- cellular response to cAMP [IEP]
- cellular response to cGMP [IEP]
- cellular response to cycloheximide [IEP]
- cellular response to dexamethasone stimulus [IEP]
- cellular response to drug [IDA]
- cellular response to fibroblast growth factor stimulus [IEP]
- cellular response to follicle-stimulating hormone stimulus [IEP]
- cellular response to glucagon stimulus [IEP]
- cellular response to glucose stimulus [IEP]
- cellular response to gravity [IEP]
- cellular response to growth factor stimulus [IEP]
- cellular response to hydrogen peroxide [IEP]
- cellular response to hypoxia [IEP]
- cellular response to insulin stimulus [IEP]
- cellular response to interleukin-1 [IDA]
- cellular response to lipopolysaccharide [ISO]
- cellular response to low-density lipoprotein particle stimulus [IEP]
- cellular response to mechanical stimulus [IEP]
- cellular response to metal ion [IEP]
- cellular response to nerve growth factor stimulus [IEP]
- cellular response to nicotine [IEP]
- cellular response to organic cyclic compound [IEP]
- cellular response to platelet-derived growth factor stimulus [IEP]
- cellular response to potassium ion [IEP]
- cellular response to transforming growth factor beta stimulus [IEP, ISO]
- chronological cell aging [ISO]
- decidualization [IEP]
- defense response to Gram-negative bacterium [ISO]
- female gonad development [IDA]
- glucose homeostasis [IEP]
- mast cell activation [IEP]
- negative regulation of cell adhesion mediated by integrin [ISO]
- negative regulation of cell migration [IDA, IMP, ISO]
- negative regulation of endopeptidase activity [IBA, IC, IDA, ISO]
- negative regulation of endothelial cell apoptotic process [ISO]
- negative regulation of extrinsic apoptotic signaling pathway via death domain receptors [ISO]
- negative regulation of fibrinolysis [ISO]
- negative regulation of gene expression [IMP]
- negative regulation of plasminogen activation [ISO]
- negative regulation of proteolysis [TAS]
- negative regulation of smooth muscle cell migration [ISO]
- negative regulation of smooth muscle cell-matrix adhesion [ISO]
- negative regulation of vascular wound healing [ISO]
- positive regulation of angiogenesis [ISO]
- positive regulation of blood coagulation [ISO]
- positive regulation of calcium ion import [IMP]
- positive regulation of coagulation [IMP]
- positive regulation of fibroblast proliferation [IMP]
- positive regulation of gene expression [IMP]
- positive regulation of inflammatory response [ISO]
- positive regulation of interleukin-8 production [ISO]
- positive regulation of keratinocyte migration [IMP]
- positive regulation of leukotriene production involved in inflammatory response [ISO]
- positive regulation of monocyte chemotaxis [ISO]
- positive regulation of receptor-mediated endocytosis [IMP, ISO]
- regulation of angiogenesis [ISO]
- regulation of cell proliferation [ISO]
- regulation of proteolysis [IBA]
- regulation of receptor activity [ISO]
- response to cytokine [IEP]
- response to epidermal growth factor [IEP]
- response to estrogen [IEP]
- response to hyperoxia [IEP]
- response to laminar fluid shear stress [IEP]
- response to lipopolysaccharide [IEP]
- response to reactive oxygen species [IEP]
- response to starvation [IEP]
- response to transforming growth factor beta [IEP]
- tissue regeneration [IEP]
- wound healing [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Rattus norvegicus
PREY
PRKCD
Pkcd
protein kinase C, delta
GO Process (48)
GO Function (9)
GO Component (10)
Gene Ontology Biological Process
- B cell proliferation [ISO]
- aging [IEP]
- apoptotic process [ISO]
- aspartate transport [IMP]
- cellular response to glucose starvation [IEP]
- cellular response to insulin stimulus [IEP]
- cellular senescence [ISO]
- collagen metabolic process [IMP]
- defense response to bacterium [ISO, ISS]
- immunoglobulin mediated immune response [ISO]
- interleukin-10 production [ISO]
- interleukin-12 production [ISO]
- intracellular signal transduction [IDA]
- negative regulation of MAP kinase activity [ISO]
- negative regulation of actin filament polymerization [ISO, ISS]
- negative regulation of filopodium assembly [ISO, ISS]
- negative regulation of glial cell apoptotic process [ISO, ISS]
- negative regulation of insulin receptor signaling pathway [ISO]
- negative regulation of peptidyl-tyrosine phosphorylation [ISO]
- negative regulation of platelet aggregation [ISO, ISS]
- neutrophil activation [ISO]
- peptidyl-threonine phosphorylation [ISO]
- positive regulation of MAP kinase activity [IMP]
- positive regulation of MAPK cascade [IMP]
- positive regulation of apoptotic process [IMP]
- positive regulation of apoptotic signaling pathway [ISO]
- positive regulation of ceramide biosynthetic process [ISO]
- positive regulation of glucose import [IMP]
- positive regulation of glucosylceramide catabolic process [ISO]
- positive regulation of phospholipid scramblase activity [ISO]
- positive regulation of protein dephosphorylation [ISO]
- positive regulation of response to DNA damage stimulus [ISO]
- positive regulation of sphingomyelin catabolic process [ISO]
- positive regulation of superoxide anion generation [ISO, ISS]
- protein autophosphorylation [IDA]
- protein phosphorylation [IDA, ISO]
- response to amino acid [IEP]
- response to drug [IEP]
- response to ethanol [IEP]
- response to glucose [IEP]
- response to heat [IEP]
- response to hydrogen peroxide [IEP]
- response to hypoxia [IEP]
- response to mechanical stimulus [IEP]
- response to organic cyclic compound [IEP]
- response to organonitrogen compound [IEP]
- response to oxidative stress [IMP]
- termination of signal transduction [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Rattus norvegicus
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Angiotensin II induces renal plasminogen activator inhibitor-1 and cyclooxygenase-2 expression post-transcriptionally via activation of the mRNA-stabilizing factor human-antigen R.
Angiotensin (Ang) II-induced fibrosis of the kidney is characterized by the enhanced expression of profibrotic and proinflammatory genes, including the serine protease inhibitor plasminogen activator inhibitor-1 (PAI-1) and cyclooxygenase-2 (COX-2). In addition to transcriptional regulation, both genes are subject to post-transcriptional control by AU-rich destabilizing elements that reside within the 3' untranslated region of the mRNA. We demonstrated that the ... [more]
Am. J. Pathol. Apr. 01, 2009; 174(4);1252-63 [Pubmed: 19246637]
Throughput
- Low Throughput
Ontology Terms
- chemical: angiotensin ii (CHEBI:48432)
Additional Notes
- interaction observed in nuclear fractions from cells treated with angiotensin II (CHEBI:48432)
Curated By
- BioGRID