BAIT
P2RX4
purinergic receptor P2X, ligand-gated ion channel 4
GO Process (24)
GO Function (9)
GO Component (16)
Gene Ontology Biological Process
- apoptotic signaling pathway [ISO]
- calcium ion transport [ISO]
- cation transmembrane transport [IDA, ISO]
- cellular response to ATP [ISO, ISS]
- ion transmembrane transport [ISO]
- membrane depolarization [ISO]
- negative regulation of cardiac muscle hypertrophy [ISO]
- neuronal action potential [IDA]
- nitric oxide biosynthetic process [ISO]
- positive regulation of calcium ion transport into cytosol [ISO]
- positive regulation of calcium-mediated signaling [ISO]
- protein homooligomerization [IDA]
- purinergic nucleotide receptor signaling pathway [ISO]
- regulation of blood pressure [ISO]
- regulation of cardiac muscle contraction [ISO]
- regulation of excitatory postsynaptic membrane potential [ISO]
- regulation of sodium ion transport [IDA]
- relaxation of cardiac muscle [ISO]
- response to ATP [ISO]
- response to fluid shear stress [ISO]
- sensory perception of pain [IMP]
- signal transduction [ISO]
- transport [ISO]
- vasodilation [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- apical part of cell [ISO]
- axon [IDA]
- cell junction [ISO]
- dendrite [IDA]
- dendritic spine [IDA]
- extracellular vesicular exosome [ISO]
- integral component of nuclear inner membrane [IBA]
- integral component of plasma membrane [ISO, ISS]
- lysosomal membrane [ISO]
- membrane [ISO]
- neuronal cell body [IDA]
- perinuclear region of cytoplasm [ISO]
- plasma membrane [IDA]
- postsynaptic density [IDA]
- synapse [IDA]
- terminal bouton [IDA]
Rattus norvegicus
PREY
AP2M1
Ap50, Clapm1, mu2
adaptor-related protein complex 2, mu 1 subunit
GO Process (2)
GO Function (3)
GO Component (6)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Rattus norvegicus
Co-crystal Structure
Interaction directly demonstrated at the atomic level by X-ray crystallography. Also used for NMR or Electron Microscopy (EM) structures. If there is no obvious bait-hit directionality to the interaction involving 3 or more proteins, then the co-crystallized proteins should be listed as a complex.
Publication
Non-canonical YXXGPhi endocytic motifs: recognition by AP2 and preferential utilization in P2X4 receptors.
During clathrin-mediated endocytosis, proteins on the cell surface are selected for inclusion in clathrin-coated vesicles by clathrin adaptors, mainly the adaptor complex AP2. The P2X4 subtype of ATP-gated ion channel has in its C-terminus two putative endocytic motifs: a canonical YXXPhi motif and a non-canonical YXXGPhi motif (YEQGL). We demonstrate that endocytosis of P2X4 receptors is mediated preferentially by the ... [more]
J. Cell. Sci. Jul. 15, 2005; 118(0);3073-80 [Pubmed: 15985462]
Throughput
- Low Throughput
Additional Notes
- P2rx4 peptide
Curated By
- BioGRID