BAIT
GJA1
Cx43
gap junction protein, alpha 1
GO Process (61)
GO Function (10)
GO Component (28)
Gene Ontology Biological Process
- ATP transport [IMP]
- adult heart development [ISO]
- apoptotic process [IMP]
- atrial ventricular junction remodeling [ISO]
- blood vessel morphogenesis [ISO]
- cardiac conduction [ISO]
- cell communication [IMP]
- cell communication by chemical coupling [ISO]
- cell communication by electrical coupling [ISO]
- cell-cell junction organization [ISO]
- cell-cell signaling [IDA, ISO]
- cellular response to mechanical stimulus [IEP]
- chronic inflammatory response [IMP]
- embryonic digit morphogenesis [ISO]
- embryonic heart tube development [ISO]
- endothelium development [IEP]
- epithelial cell maturation [ISO]
- gap junction assembly [TAS]
- heart development [IEP, ISO]
- heart looping [ISO]
- in utero embryonic development [ISO]
- lens development in camera-type eye [ISO]
- milk ejection [ISO]
- negative regulation of DNA biosynthetic process [IDA]
- negative regulation of cardiac muscle cell proliferation [IMP]
- negative regulation of cell proliferation [IDA]
- negative regulation of endothelial cell proliferation [IMP]
- negative regulation of gene expression [ISO]
- negative regulation of wound healing [IMP]
- neuron migration [ISO]
- neuron projection morphogenesis [IMP]
- osteoblast differentiation [ISO]
- positive regulation of I-kappaB kinase/NF-kappaB signaling [ISO]
- positive regulation of behavioral fear response [IMP]
- positive regulation of cell communication by chemical coupling [IMP]
- positive regulation of cytosolic calcium ion concentration [IMP]
- positive regulation of gene expression [ISO]
- positive regulation of glomerular filtration [IMP]
- positive regulation of insulin secretion [IMP]
- positive regulation of osteoblast differentiation [ISO]
- positive regulation of protein catabolic process [IDA]
- positive regulation of striated muscle tissue development [ISO]
- positive regulation of vasoconstriction [IMP]
- positive regulation of vasodilation [IMP]
- protein oligomerization [IDA]
- regulation of atrial cardiac muscle cell membrane depolarization [ISO]
- regulation of bone mineralization [ISO]
- regulation of bone remodeling [ISO]
- regulation of calcium ion transport [IMP]
- regulation of heart contraction [ISO]
- regulation of tight junction assembly [IMP]
- regulation of ventricular cardiac muscle cell membrane depolarization [ISO]
- regulation of ventricular cardiac muscle cell membrane repolarization [ISO]
- response to fluid shear stress [IEP]
- response to glucose [IEP]
- response to pH [IDA]
- response to peptide hormone [IEP]
- signal transduction [ISO]
- skeletal muscle tissue regeneration [ISO]
- transmembrane transport [IDA, ISO]
- vascular transport [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- Golgi apparatus [IDA, ISO]
- Golgi membrane [TAS]
- Golgi-associated vesicle membrane [TAS]
- apical plasma membrane [ISO]
- cell junction [ISO]
- cell-cell junction [ISO]
- connexon complex [IDA]
- contractile fiber [ISO]
- cytoplasm [IDA, ISO]
- cytosol [ISO]
- early endosome [IDA]
- endoplasmic reticulum membrane [TAS]
- endosome [IDA]
- extracellular vesicular exosome [ISO]
- fascia adherens [IDA, ISO]
- focal adhesion [ISO]
- gap junction [IDA, ISO]
- integral component of plasma membrane [TAS]
- intercalated disc [ISO]
- intermediate filament [ISO]
- late endosome [IDA]
- lateral plasma membrane [ISO]
- lysosome [IDA]
- membrane [IDA, ISO]
- membrane raft [IDA]
- mitochondrial outer membrane [IDA]
- multivesicular body [IDA]
- plasma membrane [IDA, IMP, ISO, TAS]
Rattus norvegicus
PREY
ANXA1
Anx1, p35
annexin A1
GO Process (39)
GO Function (12)
GO Component (14)
Gene Ontology Biological Process
- ATP catabolic process [IMP]
- DNA duplex unwinding [IMP]
- DNA rewinding [IMP]
- DNA strand renaturation [IMP]
- alpha-beta T cell differentiation [ISO]
- arachidonic acid secretion [ISO]
- cell surface receptor signaling pathway [IDA]
- cellular response to glucocorticoid stimulus [IDA, ISO]
- cellular response to hydrogen peroxide [IMP]
- endocrine pancreas development [IEP]
- estrous cycle phase [IEP]
- gliogenesis [IEP]
- hepatocyte differentiation [IEP]
- insulin secretion [IDA]
- keratinocyte differentiation [ISO]
- negative regulation of interleukin-8 secretion [ISO]
- negative regulation of phospholipase A2 activity [IDA]
- negative regulation of protein secretion [IMP]
- neutrophil clearance [ISO]
- neutrophil homeostasis [ISO]
- peptide cross-linking [ISO]
- positive regulation of G1/S transition of mitotic cell cycle [ISO]
- positive regulation of apoptotic process [IMP]
- positive regulation of neutrophil apoptotic process [ISO]
- positive regulation of prostaglandin biosynthetic process [IMP]
- positive regulation of vesicle fusion [ISO]
- prolactin secretion [IMP]
- prostate gland development [IEP]
- regulation of cell proliferation [ISO]
- response to X-ray [IEP]
- response to corticosteroid [IEP]
- response to drug [IEP]
- response to estradiol [IEP]
- response to glucocorticoid [IEP]
- response to hormone [IEP]
- response to interleukin-1 [IEP]
- response to organic cyclic compound [IEP]
- response to peptide hormone [IEP]
- signal transduction [ISO]
Gene Ontology Molecular Function- annealing helicase activity [IMP]
- calcium-dependent phospholipid binding [ISO, TAS]
- calcium-dependent protein binding [ISO]
- double-stranded DNA-dependent ATPase activity [IMP]
- helicase activity [IMP]
- phospholipase A2 inhibitor activity [IDA, ISO]
- phospholipid binding [IDA]
- protein binding, bridging [ISO]
- protein homodimerization activity [IDA]
- single-stranded DNA binding [IDA]
- single-stranded RNA binding [IDA]
- structural molecule activity [ISO]
- annealing helicase activity [IMP]
- calcium-dependent phospholipid binding [ISO, TAS]
- calcium-dependent protein binding [ISO]
- double-stranded DNA-dependent ATPase activity [IMP]
- helicase activity [IMP]
- phospholipase A2 inhibitor activity [IDA, ISO]
- phospholipid binding [IDA]
- protein binding, bridging [ISO]
- protein homodimerization activity [IDA]
- single-stranded DNA binding [IDA]
- single-stranded RNA binding [IDA]
- structural molecule activity [ISO]
Gene Ontology Cellular Component
- cell surface [ISO]
- cornified envelope [ISO]
- cytoplasm [IDA, ISO]
- endosome [ISO]
- extracellular space [IDA, ISO]
- extracellular vesicular exosome [ISO]
- focal adhesion [ISO]
- mast cell granule [IDA]
- mitochondrial membrane [IDA]
- nucleus [IDA, ISO]
- plasma membrane [IDA, ISO]
- protein complex [IDA]
- sarcolemma [ISO]
- vesicle [ISO]
Rattus norvegicus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Association of connexin43 with E3 ubiquitin ligase TRIM21 reveals a mechanism for gap junction phosphodegron control.
Gap junctions (GJs) are sites of direct cell-to-cell communication formed by the connexin (Cx) family of ion channel proteins. The aberrant intercellular communication mediated by GJs is associated with a variety of hereditary and acquired human diseases. GJs utilize a highly interconnected network that is indispensible for synthesis, trafficking and degradation of their constituent proteins. By unbiased proteomic examination and ... [more]
J. Proteome Res. Dec. 07, 2012; 11(12);6134-46 [Pubmed: 23106098]
Throughput
- High Throughput
Curated By
- BioGRID