BAIT
GJA1
Cx43
gap junction protein, alpha 1
GO Process (61)
GO Function (10)
GO Component (28)
Gene Ontology Biological Process
- ATP transport [IMP]
- adult heart development [ISO]
- apoptotic process [IMP]
- atrial ventricular junction remodeling [ISO]
- blood vessel morphogenesis [ISO]
- cardiac conduction [ISO]
- cell communication [IMP]
- cell communication by chemical coupling [ISO]
- cell communication by electrical coupling [ISO]
- cell-cell junction organization [ISO]
- cell-cell signaling [IDA, ISO]
- cellular response to mechanical stimulus [IEP]
- chronic inflammatory response [IMP]
- embryonic digit morphogenesis [ISO]
- embryonic heart tube development [ISO]
- endothelium development [IEP]
- epithelial cell maturation [ISO]
- gap junction assembly [TAS]
- heart development [IEP, ISO]
- heart looping [ISO]
- in utero embryonic development [ISO]
- lens development in camera-type eye [ISO]
- milk ejection [ISO]
- negative regulation of DNA biosynthetic process [IDA]
- negative regulation of cardiac muscle cell proliferation [IMP]
- negative regulation of cell proliferation [IDA]
- negative regulation of endothelial cell proliferation [IMP]
- negative regulation of gene expression [ISO]
- negative regulation of wound healing [IMP]
- neuron migration [ISO]
- neuron projection morphogenesis [IMP]
- osteoblast differentiation [ISO]
- positive regulation of I-kappaB kinase/NF-kappaB signaling [ISO]
- positive regulation of behavioral fear response [IMP]
- positive regulation of cell communication by chemical coupling [IMP]
- positive regulation of cytosolic calcium ion concentration [IMP]
- positive regulation of gene expression [ISO]
- positive regulation of glomerular filtration [IMP]
- positive regulation of insulin secretion [IMP]
- positive regulation of osteoblast differentiation [ISO]
- positive regulation of protein catabolic process [IDA]
- positive regulation of striated muscle tissue development [ISO]
- positive regulation of vasoconstriction [IMP]
- positive regulation of vasodilation [IMP]
- protein oligomerization [IDA]
- regulation of atrial cardiac muscle cell membrane depolarization [ISO]
- regulation of bone mineralization [ISO]
- regulation of bone remodeling [ISO]
- regulation of calcium ion transport [IMP]
- regulation of heart contraction [ISO]
- regulation of tight junction assembly [IMP]
- regulation of ventricular cardiac muscle cell membrane depolarization [ISO]
- regulation of ventricular cardiac muscle cell membrane repolarization [ISO]
- response to fluid shear stress [IEP]
- response to glucose [IEP]
- response to pH [IDA]
- response to peptide hormone [IEP]
- signal transduction [ISO]
- skeletal muscle tissue regeneration [ISO]
- transmembrane transport [IDA, ISO]
- vascular transport [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- Golgi apparatus [IDA, ISO]
- Golgi membrane [TAS]
- Golgi-associated vesicle membrane [TAS]
- apical plasma membrane [ISO]
- cell junction [ISO]
- cell-cell junction [ISO]
- connexon complex [IDA]
- contractile fiber [ISO]
- cytoplasm [IDA, ISO]
- cytosol [ISO]
- early endosome [IDA]
- endoplasmic reticulum membrane [TAS]
- endosome [IDA]
- extracellular vesicular exosome [ISO]
- fascia adherens [IDA, ISO]
- focal adhesion [ISO]
- gap junction [IDA, ISO]
- integral component of plasma membrane [TAS]
- intercalated disc [ISO]
- intermediate filament [ISO]
- late endosome [IDA]
- lateral plasma membrane [ISO]
- lysosome [IDA]
- membrane [IDA, ISO]
- membrane raft [IDA]
- mitochondrial outer membrane [IDA]
- multivesicular body [IDA]
- plasma membrane [IDA, IMP, ISO, TAS]
Rattus norvegicus
PREY
SOD1
CuZnSOD
superoxide dismutase 1, soluble
GO Process (60)
GO Function (8)
GO Component (22)
Gene Ontology Biological Process
- activation of MAPK activity [ISO, ISS]
- aging [ISO]
- anterograde axon cargo transport [ISO]
- apoptotic DNA fragmentation [ISS]
- auditory receptor cell stereocilium organization [ISO, ISS]
- cell aging [ISO, ISS]
- cellular iron ion homeostasis [ISO, ISS]
- cellular response to ATP [IEP]
- cellular response to cadmium ion [IEP]
- cellular response to oxidative stress [IEP]
- cellular response to potassium ion [IEP]
- double-strand break repair [ISS]
- embryo implantation [ISO, ISS]
- glutathione metabolic process [ISO, ISS]
- heart contraction [ISO, ISS]
- hydrogen peroxide biosynthetic process [IDA, IMP, ISO, ISS]
- locomotory behavior [ISO, ISS]
- muscle cell cellular homeostasis [ISO, ISS]
- myeloid cell homeostasis [ISO, ISS]
- negative regulation of apoptotic process [IMP, ISO]
- negative regulation of cholesterol biosynthetic process [ISO, ISS]
- negative regulation of neuron apoptotic process [ISO, ISS]
- neurofilament cytoskeleton organization [ISO, ISS]
- ovarian follicle development [ISO, ISS]
- oxidation-reduction process [ISO]
- peripheral nervous system myelin maintenance [ISO, ISS]
- positive regulation of catalytic activity [IDA, ISO, ISS]
- positive regulation of cytokine production [ISO, ISS]
- positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway [ISO]
- positive regulation of superoxide anion generation [ISO]
- reactive oxygen species metabolic process [ISO, ISS]
- regulation of Rac GTPase activity [ISO]
- regulation of blood pressure [ISO, ISS]
- regulation of mitochondrial membrane potential [ISO, ISS]
- regulation of multicellular organism growth [ISO, ISS]
- regulation of protein kinase activity [ISO, ISS]
- relaxation of vascular smooth muscle [ISO, ISS]
- removal of superoxide radicals [IDA, IMP, ISO, ISS, TAS]
- response to amphetamine [IEP]
- response to antibiotic [IEP]
- response to antipsychotic drug [IEP]
- response to axon injury [ISO, ISS]
- response to carbon monoxide [IEP]
- response to copper ion [IEP, IMP]
- response to drug [ISO, ISS]
- response to ethanol [ISO, ISS]
- response to heat [ISO, ISS]
- response to hydrogen peroxide [ISO, ISS]
- response to nutrient levels [IDA, IEP]
- response to organic substance [ISO, ISS]
- response to oxidative stress [IMP, ISO, TAS]
- response to reactive oxygen species [ISO]
- response to superoxide [ISO, ISS]
- retina homeostasis [ISO, ISS]
- retrograde axon cargo transport [ISO]
- sensory perception of sound [ISO, ISS]
- spermatogenesis [ISO, ISS]
- superoxide anion generation [ISO]
- superoxide metabolic process [IDA, ISO, ISS, TAS]
- transmission of nerve impulse [ISO, ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- cell [ISO]
- cytoplasm [IDA, ISO, ISS]
- cytoplasmic vesicle [ISO, ISS]
- cytosol [ISO, ISS]
- dendrite cytoplasm [ISO, ISS]
- dense core granule [IDA]
- extracellular matrix [ISO, ISS]
- extracellular region [IDA]
- extracellular space [ISO, ISS]
- extracellular vesicular exosome [ISO]
- intracellular [ISO]
- mitochondrial intermembrane space [IDA]
- mitochondrion [IDA, ISO, ISS]
- myelin sheath [ISO]
- neuron projection [IDA]
- neuronal cell body [IDA, ISO, ISS]
- nucleoplasm [ISO]
- nucleus [IDA, ISO, ISS]
- peroxisome [IDA, ISO]
- plasma membrane [ISO, ISS]
- protein complex [IDA, ISO, ISS]
- secretory granule [IDA]
Rattus norvegicus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Association of connexin43 with E3 ubiquitin ligase TRIM21 reveals a mechanism for gap junction phosphodegron control.
Gap junctions (GJs) are sites of direct cell-to-cell communication formed by the connexin (Cx) family of ion channel proteins. The aberrant intercellular communication mediated by GJs is associated with a variety of hereditary and acquired human diseases. GJs utilize a highly interconnected network that is indispensible for synthesis, trafficking and degradation of their constituent proteins. By unbiased proteomic examination and ... [more]
J. Proteome Res. Dec. 07, 2012; 11(12);6134-46 [Pubmed: 23106098]
Throughput
- High Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| GJA1 SOD1 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | - | BioGRID | 2448725 |
Curated By
- BioGRID