BAIT
GJA1
Cx43
gap junction protein, alpha 1
GO Process (61)
GO Function (10)
GO Component (28)
Gene Ontology Biological Process
- ATP transport [IMP]
- adult heart development [ISO]
- apoptotic process [IMP]
- atrial ventricular junction remodeling [ISO]
- blood vessel morphogenesis [ISO]
- cardiac conduction [ISO]
- cell communication [IMP]
- cell communication by chemical coupling [ISO]
- cell communication by electrical coupling [ISO]
- cell-cell junction organization [ISO]
- cell-cell signaling [IDA, ISO]
- cellular response to mechanical stimulus [IEP]
- chronic inflammatory response [IMP]
- embryonic digit morphogenesis [ISO]
- embryonic heart tube development [ISO]
- endothelium development [IEP]
- epithelial cell maturation [ISO]
- gap junction assembly [TAS]
- heart development [IEP, ISO]
- heart looping [ISO]
- in utero embryonic development [ISO]
- lens development in camera-type eye [ISO]
- milk ejection [ISO]
- negative regulation of DNA biosynthetic process [IDA]
- negative regulation of cardiac muscle cell proliferation [IMP]
- negative regulation of cell proliferation [IDA]
- negative regulation of endothelial cell proliferation [IMP]
- negative regulation of gene expression [ISO]
- negative regulation of wound healing [IMP]
- neuron migration [ISO]
- neuron projection morphogenesis [IMP]
- osteoblast differentiation [ISO]
- positive regulation of I-kappaB kinase/NF-kappaB signaling [ISO]
- positive regulation of behavioral fear response [IMP]
- positive regulation of cell communication by chemical coupling [IMP]
- positive regulation of cytosolic calcium ion concentration [IMP]
- positive regulation of gene expression [ISO]
- positive regulation of glomerular filtration [IMP]
- positive regulation of insulin secretion [IMP]
- positive regulation of osteoblast differentiation [ISO]
- positive regulation of protein catabolic process [IDA]
- positive regulation of striated muscle tissue development [ISO]
- positive regulation of vasoconstriction [IMP]
- positive regulation of vasodilation [IMP]
- protein oligomerization [IDA]
- regulation of atrial cardiac muscle cell membrane depolarization [ISO]
- regulation of bone mineralization [ISO]
- regulation of bone remodeling [ISO]
- regulation of calcium ion transport [IMP]
- regulation of heart contraction [ISO]
- regulation of tight junction assembly [IMP]
- regulation of ventricular cardiac muscle cell membrane depolarization [ISO]
- regulation of ventricular cardiac muscle cell membrane repolarization [ISO]
- response to fluid shear stress [IEP]
- response to glucose [IEP]
- response to pH [IDA]
- response to peptide hormone [IEP]
- signal transduction [ISO]
- skeletal muscle tissue regeneration [ISO]
- transmembrane transport [IDA, ISO]
- vascular transport [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- Golgi apparatus [IDA, ISO]
- Golgi membrane [TAS]
- Golgi-associated vesicle membrane [TAS]
- apical plasma membrane [ISO]
- cell junction [ISO]
- cell-cell junction [ISO]
- connexon complex [IDA]
- contractile fiber [ISO]
- cytoplasm [IDA, ISO]
- cytosol [ISO]
- early endosome [IDA]
- endoplasmic reticulum membrane [TAS]
- endosome [IDA]
- extracellular vesicular exosome [ISO]
- fascia adherens [IDA, ISO]
- focal adhesion [ISO]
- gap junction [IDA, ISO]
- integral component of plasma membrane [TAS]
- intercalated disc [ISO]
- intermediate filament [ISO]
- late endosome [IDA]
- lateral plasma membrane [ISO]
- lysosome [IDA]
- membrane [IDA, ISO]
- membrane raft [IDA]
- mitochondrial outer membrane [IDA]
- multivesicular body [IDA]
- plasma membrane [IDA, IMP, ISO, TAS]
Rattus norvegicus
PREY
SERPINE2
Gdnpn1, PI-7, Pn-1, Spin4
serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
GO Process (30)
GO Function (4)
GO Component (11)
Gene Ontology Biological Process
- blood coagulation [ISO]
- cerebellar granular layer morphogenesis [ISO]
- dense core granule biogenesis [IDA]
- detection of mechanical stimulus involved in sensory perception [ISO]
- embryo implantation [IEP]
- innervation [ISO]
- long-term synaptic potentiation [ISO]
- mating plug formation [ISO]
- negative regulation of blood coagulation [IDA, ISO]
- negative regulation of cell growth [ISO]
- negative regulation of cell proliferation [ISO]
- negative regulation of endopeptidase activity [IBA, ISO]
- negative regulation of peptidase activity [ISO]
- negative regulation of phosphatidylinositol 3-kinase signaling [ISO]
- negative regulation of plasminogen activation [ISO]
- negative regulation of platelet activation [ISO]
- negative regulation of platelet aggregation [ISO]
- negative regulation of protein catabolic process [ISO]
- negative regulation of proteolysis [IDA, ISO]
- negative regulation of smoothened signaling pathway [ISO]
- negative regulation of sodium ion transport [ISO]
- positive regulation of astrocyte differentiation [ISO]
- positive regulation of neuron projection development [IDA]
- regulation of synaptic transmission, glutamatergic [ISO]
- regulation of timing of cell differentiation [ISO]
- response to radiation [IEP]
- response to wounding [ISO]
- secretion by cell [ISO]
- secretory granule organization [IDA, ISO]
- seminal vesicle epithelium development [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Rattus norvegicus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Association of connexin43 with E3 ubiquitin ligase TRIM21 reveals a mechanism for gap junction phosphodegron control.
Gap junctions (GJs) are sites of direct cell-to-cell communication formed by the connexin (Cx) family of ion channel proteins. The aberrant intercellular communication mediated by GJs is associated with a variety of hereditary and acquired human diseases. GJs utilize a highly interconnected network that is indispensible for synthesis, trafficking and degradation of their constituent proteins. By unbiased proteomic examination and ... [more]
J. Proteome Res. Dec. 07, 2012; 11(12);6134-46 [Pubmed: 23106098]
Throughput
- High Throughput
Curated By
- BioGRID