BAIT

GJA1

Cx43
gap junction protein, alpha 1
GO Process (61)
GO Function (10)
GO Component (28)

Gene Ontology Biological Process

Rattus norvegicus
PREY

RPLP1

ribosomal protein, large, P1
GO Process (0)
GO Function (0)
GO Component (4)
Rattus norvegicus

Affinity Capture-MS

An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.

Publication

Association of connexin43 with E3 ubiquitin ligase TRIM21 reveals a mechanism for gap junction phosphodegron control.

Chen VC, Kristensen AR, Foster LJ, Naus CC

Gap junctions (GJs) are sites of direct cell-to-cell communication formed by the connexin (Cx) family of ion channel proteins. The aberrant intercellular communication mediated by GJs is associated with a variety of hereditary and acquired human diseases. GJs utilize a highly interconnected network that is indispensible for synthesis, trafficking and degradation of their constituent proteins. By unbiased proteomic examination and ... [more]

J. Proteome Res. Dec. 07, 2012; 11(12);6134-46 [Pubmed: 23106098]

Throughput

  • High Throughput

Curated By

  • BioGRID