PLCB3
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
GNAQ
Gene Ontology Biological Process
- G-protein coupled receptor signaling pathway [IMP, ISO]
- GTP catabolic process [IBA]
- action potential [IMP]
- activation of phospholipase C activity [ISO]
- adenylate cyclase-activating G-protein coupled receptor signaling pathway [IDA]
- developmental pigmentation [IMP]
- embryonic digit morphogenesis [IGI]
- forebrain neuron development [IMP]
- glutamate receptor signaling pathway [IMP]
- heart development [IMP]
- maternal behavior [IMP]
- negative regulation of apoptotic process [ISO]
- negative regulation of potassium ion transport [ISO]
- negative regulation of protein kinase activity [ISO]
- neuron remodeling [IMP]
- phospholipase C-activating G-protein coupled receptor signaling pathway [ISO]
- phospholipase C-activating dopamine receptor signaling pathway [IGI]
- positive regulation of GTPase activity [IBA, ISO]
- positive regulation of smooth muscle cell proliferation [ISO]
- post-embryonic development [IMP]
- protein stabilization [ISO]
- regulation of catenin import into nucleus [ISO]
- regulation of melanocyte differentiation [IMP]
- signal transduction [IBA]
- skeletal system development [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Co-crystal Structure
Interaction directly demonstrated at the atomic level by X-ray crystallography. Also used for NMR or Electron Microscopy (EM) structures. If there is no obvious bait-hit directionality to the interaction involving 3 or more proteins, then the co-crystallized proteins should be listed as a complex.
Publication
Full-length Gα(q)-phospholipase C-β3 structure reveals interfaces of the C-terminal coiled-coil domain.
Phospholipase C-β (PLCβ) is directly activated by Gαq, but the molecular basis for how its distal C-terminal domain (CTD) contributes to maximal activity is poorly understood. Herein we present both the crystal structure and cryo-EM three-dimensional reconstructions of human full-length PLCβ3 in complex with mouse Gαq. The distal CTD forms an extended monomeric helical bundle consisting of three antiparallel segments ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| PLCB3 GNAQ | Co-crystal Structure Co-crystal Structure Interaction directly demonstrated at the atomic level by X-ray crystallography. Also used for NMR or Electron Microscopy (EM) structures. If there is no obvious bait-hit directionality to the interaction involving 3 or more proteins, then the co-crystallized proteins should be listed as a complex. | Low | - | BioGRID | 908032 |
Curated By
- BioGRID