KCNMB1
Gene Ontology Biological Process
Gene Ontology Cellular Component
KCNMA1
Gene Ontology Biological Process
- blood coagulation [TAS]
- cellular potassium ion homeostasis [IDA]
- micturition [IDA]
- negative regulation of cell volume [IDA]
- positive regulation of apoptotic process [IMP]
- potassium ion transmembrane transport [IBA, IDA]
- potassium ion transport [IDA]
- regulation of membrane potential [IDA]
- response to calcium ion [IDA]
- response to carbon monoxide [IDA, IMP]
- response to hypoxia [IDA]
- response to osmotic stress [IDA]
- smooth muscle contraction involved in micturition [IDA]
- synaptic transmission [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
The β1-subunit of the MaxiK channel associates with the thromboxane A2 receptor and reduces thromboxane A2 functional effects.
The large conductance voltage- and Ca(2+)-activated K(+) channel (MaxiK, BK(Ca), BK) is composed of four pore-forming α-subunits and can be associated with regulatory β-subunits. One of the functional roles of MaxiK is to regulate vascular tone. We recently found that the MaxiK channel from coronary smooth muscle is trans-inhibited by activation of the vasoconstricting thromboxane A(2) prostanoid receptor (TP), a ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID