RNH70
Gene Ontology Biological Process
Gene Ontology Molecular Function
RRP6
Gene Ontology Biological Process
- U1 snRNA 3'-end processing [IGI, IMP]
- U4 snRNA 3'-end processing [IGI, IMP]
- U5 snRNA 3'-end processing [IGI, IMP]
- exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [IMP]
- histone mRNA catabolic process [IMP]
- nuclear polyadenylation-dependent CUT catabolic process [IGI, IMP]
- nuclear polyadenylation-dependent antisense transcript catabolic process [IMP]
- nuclear polyadenylation-dependent mRNA catabolic process [IMP]
- nuclear polyadenylation-dependent rRNA catabolic process [IGI, IMP]
- nuclear polyadenylation-dependent snRNA catabolic process [IMP]
- nuclear polyadenylation-dependent snoRNA catabolic process [IMP]
- nuclear polyadenylation-dependent tRNA catabolic process [IDA, IGI]
- nuclear retention of pre-mRNA at the site of transcription [IGI]
- nuclear retention of pre-mRNA with aberrant 3'-ends at the site of transcription [IGI]
- polyadenylation-dependent snoRNA 3'-end processing [IMP]
- posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery [IMP]
Gene Ontology Molecular Function
Dosage Rescue
A genetic interaction is inferred when over expression or increased dosage of one gene rescues the lethality or growth defect of a strain that is mutated or deleted for another gene.
Publication
The Exosome Cofactor Rrp47 Is Critical for the Stability and Normal Expression of Its Associated Exoribonuclease Rrp6 in Saccharomyces cerevisiae.
Rrp6 is a conserved catalytic subunit of the eukaryotic nuclear exosome ribonuclease complex that functions in the productive 3' end maturation of stable RNAs, the degradation of transiently expressed noncoding transcripts and in discard pathways that eradicate the cell of incorrectly processed or assembled RNAs. The function of Rrp6 in these pathways is at least partially dependent upon its interaction ... [more]
Throughput
- Low Throughput
Ontology Terms
- phenotype: viability (APO:0000111)
Additional Notes
- rrp47 rex1 or rrp47 mpp6 double mutants could be rescued by over-expression of Rrp6
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| RRP6 RNH70 | Dosage Rescue Dosage Rescue A genetic interaction is inferred when over expression or increased dosage of one gene rescues the lethality or growth defect of a strain that is mutated or deleted for another gene. | Low | - | BioGRID | 213369 | |
| RRP6 RNH70 | Negative Genetic Negative Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores. | High | -0.2142 | BioGRID | 413994 | |
| RRP6 RNH70 | Negative Genetic Negative Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores. | High | -0.165 | BioGRID | 2181093 | |
| RNH70 RRP6 | Negative Genetic Negative Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores. | High | -0.6506 | BioGRID | 2124270 | |
| RRP6 RNH70 | Negative Genetic Negative Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores. | High | - | BioGRID | 3395255 |
Curated By
- BioGRID