BAIT

PDR1

AMY1, ANT1, BOR2, CYH3, NRA2, SMR2, TIL1, TPE1, TPE3, drug-responsive transcription factor PDR1, L000002984, L000003503, L000001361, YGL013C
Transcription factor that regulates the pleiotropic drug response; zinc cluster protein that is a master regulator involved in recruiting other zinc cluster proteins to pleiotropic drug response elements (PDREs) to fine tune the regulation of multidrug resistance genes; relocalizes to the cytosol in response to hypoxia; PDR1 has a paralog, PDR3, that arose from the whole genome duplication
Saccharomyces cerevisiae (S288c)
PREY

BEM2

IPL2, SUP9, TSL1, L000000168, YER155C
Rho GTPase activating protein (RhoGAP); involved in the control of cytoskeleton organization and cellular morphogenesis; required for bud emergence; potential GAP for Rho4p
Saccharomyces cerevisiae (S288c)

Phenotypic Enhancement

A genetic interaction is inferred when mutation or overexpression of one gene results in enhancement of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene.

Publication

Networks of genes modulating the pleiotropic drug response in Saccharomyces cerevisiae.

Yibmantasiri P, Bircham PW, Maass DR, Bellows DS, Atkinson PH

The pleiotropic drug response (PDR) or multidrug resistance (MDR) are cellular defence mechanisms present in all species to deal with potential toxicity from environmental small molecule toxins or bioactives. The rapid induction of MDR by xenobiotics in mammalian cells and PDR in budding yeast (S. cerevisiae) has been well studied but how pathway specificity is achieved across different structural classes ... [more]

Mol Biosyst Nov. 08, 2013; 0(0); [Pubmed: 24201294]

Throughput

  • Low Throughput

Ontology Terms

  • resistance to chemicals (APO:0000087)

Additional Notes

  • pdr1 pdr3 bem2 triple mutants showed increased sensitivity to compounds over that showed by pdr1 pdr3 double mutants, implying the existence of PDR mechanisms outside of the PDR1 PDR3 route

Related interactions

InteractionExperimental Evidence CodeDatasetThroughputScoreCurated ByNotes
PDR1 BEM2
Negative Genetic
Negative Genetic

Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores.

High-0.1665BioGRID
2113942

Curated By

  • BioGRID