BAIT

HST4

L000003043, YDR191W
Member of the Sir2 family of NAD(+)-dependent protein deacetylases; involved along with Hst3p in silencing at telomeres, cell cycle progression, radiation resistance, genomic stability and short-chain fatty acid metabolism
GO Process (3)
GO Function (1)
GO Component (2)

Gene Ontology Biological Process

Gene Ontology Molecular Function

Gene Ontology Cellular Component

Saccharomyces cerevisiae (S288c)
PREY

POL2

DUN2, DNA polymerase epsilon catalytic subunit, L000001461, YNL262W
Catalytic subunit of DNA polymerase (II) epsilon; a chromosomal DNA replication polymerase that exhibits processivity and proofreading exonuclease activity; participates in leading-strand synthesis during DNA replication; also involved in DNA synthesis during DNA repair; interacts extensively with Mrc1p
Saccharomyces cerevisiae (S288c)

Phenotypic Enhancement

A genetic interaction is inferred when mutation or overexpression of one gene results in enhancement of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene.

Publication

A reversible histone h3 acetylation cooperates with mismatch repair and replicative polymerases in maintaining genome stability.

Kadyrova LY, Mertz TM, Zhang Y, Northam MR, Sheng Z, Lobachev KS, Shcherbakova PV, Kadyrov FA

Mutations are a major driving force of evolution and genetic disease. In eukaryotes, mutations are produced in the chromatin environment, but the impact of chromatin on mutagenesis is poorly understood. Previous studies have determined that in yeast Saccharomyces cerevisiae, Rtt109-dependent acetylation of histone H3 on K56 is an abundant modification that is introduced in chromatin in S phase and removed ... [more]

PLoS Genet. Oct. 01, 2013; 9(10);e1003899 [Pubmed: 24204308]

Throughput

  • Low Throughput

Ontology Terms

  • phenotype: mutation frequency (APO:0000198)

Additional Notes

  • hst3 hst4 pol2-4 triple mutant had a more extreme mutator phenotype

Related interactions

InteractionExperimental Evidence CodeDatasetThroughputScoreCurated ByNotes
HST4 POL2
Synthetic Lethality
Synthetic Lethality

A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.

Low-BioGRID
479585

Curated By

  • BioGRID