ANCE
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
KNG1
Gene Ontology Biological Process
- blood coagulation [TAS]
- blood coagulation, intrinsic pathway [TAS]
- inflammatory response [TAS]
- negative regulation of blood coagulation [IDA]
- negative regulation of cell adhesion [IDA]
- negative regulation of endopeptidase activity [IDA]
- negative regulation of proteolysis [IDA]
- platelet activation [TAS]
- platelet degranulation [TAS]
- positive regulation of apoptotic process [NAS]
- positive regulation of cytosolic calcium ion concentration [IDA]
- positive regulation of renal sodium excretion [TAS]
- positive regulation of urine volume [TAS]
- smooth muscle contraction [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Co-crystal Structure
Interaction directly demonstrated at the atomic level by X-ray crystallography. Also used for NMR or Electron Microscopy (EM) structures. If there is no obvious bait-hit directionality to the interaction involving 3 or more proteins, then the co-crystallized proteins should be listed as a complex.
Publication
Structural basis of peptide recognition by the angiotensin-1 converting enzyme homologue AnCE from Drosophila melanogaster.
Human somatic angiotensin-1 converting enzyme (ACE) is a zinc-dependent exopeptidase, that catalyses the conversion of the decapeptide angiotensin I to the octapeptide angiotensin II, by removing a C-terminal dipeptide. It is the principal component of the renin-angiotensin-aldosterone system that regulates blood pressure. Hence it is an important therapeutic target for the treatment of hypertension and cardiovascular disorders. Here, we report the structures ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID