FBXO6
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
ITGA3
Gene Ontology Biological Process
- blood coagulation [TAS]
- cell-matrix adhesion [TAS]
- extracellular matrix organization [TAS]
- leukocyte migration [TAS]
- lung development [IMP]
- mesodermal cell differentiation [IEP]
- nephron development [IMP]
- positive regulation of establishment of protein localization to plasma membrane [IDA]
- regulation of BMP signaling pathway [IMP]
- regulation of Wnt signaling pathway [IMP]
- regulation of transforming growth factor beta receptor signaling pathway [IMP]
- renal filtration [IMP]
- skin development [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Proteomic identification of common SCF ubiquitin ligase FBXO6-interacting glycoproteins in three kinds of cells.
FBOX6 ubiquitin ligase complex is involved in the endoplasmic reticulum-associated degradation pathway by mediating the ubiquitination of glycoproteins. FBXO6 interacts with the chitobiose in unfolded N-glycoprotein, pointing glycoproteins toward E2 for ubiquitination. Although the glycoprotein-recognizing mechanism of FBXO6 is well documented, its bona fide interacting glycoproteins are largely unknown. Here we utilized a protein purification approach combined with LC-MS to ... [more]
Throughput
- High Throughput
Ontology Terms
- cell line: hela cell (BTO:0000567)
- disease: cervical adenocarcinoma (DOID:3702)
Additional Notes
- exogenous expression of bait
Related interactions
Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
---|---|---|---|---|---|---|
FBXO6 ITGA3 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | - | BioGRID | - |
Curated By
- BioGRID