BAIT
FBXO6
FBG2, FBS2, FBX6, Fbx6b, RP3-330O12.3
F-box protein 6
GO Process (5)
GO Function (2)
GO Component (2)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
ARHGEF2
GEF, GEF-H1, GEFH1, LFP40, P40, RP11-336K24.3
Rho/Rac guanine nucleotide exchange factor (GEF) 2
GO Process (24)
GO Function (8)
GO Component (8)
Gene Ontology Biological Process
- actin filament organization [IMP]
- apoptotic signaling pathway [TAS]
- cell morphogenesis [IMP]
- cellular hyperosmotic response [ISS]
- cellular response to muramyl dipeptide [IDA]
- cellular response to tumor necrosis factor [ISS]
- intracellular protein transport [NAS]
- negative regulation of extrinsic apoptotic signaling pathway via death domain receptors [ISS]
- negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress [ISS]
- negative regulation of microtubule depolymerization [IMP]
- negative regulation of necroptotic process [ISS]
- neurotrophin TRK receptor signaling pathway [TAS]
- positive regulation of NF-kappaB transcription factor activity [IDA]
- positive regulation of Rac GTPase activity [IDA]
- positive regulation of Rho GTPase activity [IDA]
- positive regulation of apoptotic process [TAS]
- positive regulation of interleukin-6 production [IDA]
- positive regulation of peptidyl-tyrosine phosphorylation [IDA]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- positive regulation of tumor necrosis factor production [IDA]
- regulation of Rho protein signal transduction [NAS]
- regulation of cell proliferation [TAS]
- regulation of small GTPase mediated signal transduction [TAS]
- small GTPase mediated signal transduction [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Proteomic identification of common SCF ubiquitin ligase FBXO6-interacting glycoproteins in three kinds of cells.
FBOX6 ubiquitin ligase complex is involved in the endoplasmic reticulum-associated degradation pathway by mediating the ubiquitination of glycoproteins. FBXO6 interacts with the chitobiose in unfolded N-glycoprotein, pointing glycoproteins toward E2 for ubiquitination. Although the glycoprotein-recognizing mechanism of FBXO6 is well documented, its bona fide interacting glycoproteins are largely unknown. Here we utilized a protein purification approach combined with LC-MS to ... [more]
J. Proteome Res. Mar. 02, 2012; 11(3);1773-81 [Pubmed: 22268729]
Throughput
- High Throughput
Ontology Terms
- jurkat cell (BTO:0000661)
- t-cell leukemia (DOID:715)
Additional Notes
- exogenous expression of bait
Curated By
- BioGRID