BAIT
PPP6R1
KIAA1115, PP6R1, SAP190, SAPS1
protein phosphatase 6, regulatory subunit 1
GO Process (1)
GO Function (2)
GO Component (1)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Homo sapiens
PREY
SRPRB
APMCF1, PSEC0230
signal recognition particle receptor, B subunit
GO Process (6)
GO Function (0)
GO Component (4)
Gene Ontology Biological Process
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Protein interaction network of the Mammalian hippo pathway reveals mechanisms of kinase-phosphatase interactions.
The Hippo pathway regulates organ size and tissue homeostasis in response to multiple stimuli, including cell density and mechanotransduction. Pharmacological inhibition of phosphatases can also stimulate Hippo signaling in cell culture. We defined the Hippo protein-protein interaction network with and without inhibition of serine and threonine phosphatases by okadaic acid. We identified 749 protein interactions, including 599 previously unrecognized interactions, ... [more]
Sci Signal Nov. 21, 2013; 6(302);rs15 [Pubmed: 24255178]
Quantitative Score
- 0.96 [Saint Score]
Throughput
- High Throughput
Curated By
- BioGRID