TRPV1
Gene Ontology Biological Process
- behavioral response to pain [IMP]
- calcium ion transmembrane transport [IMP, ISO]
- calcium ion transport [IDA, IMP, ISO]
- catagen [IMP]
- cation transmembrane transport [ISA]
- cation transport [ISA]
- cellular response to ATP [ISO]
- cellular response to alkaloid [ISO]
- cellular response to cytokine stimulus [ISO]
- detection of chemical stimulus involved in sensory perception of pain [IDA, IMP]
- diet induced thermogenesis [IMP]
- fever generation [IMP]
- glutamate secretion [ISO]
- ion transmembrane transport [IDA]
- lipid metabolic process [IMP]
- microglial cell activation [ISO]
- negative regulation of establishment of blood-brain barrier [ISO]
- peptide secretion [IMP]
- positive regulation of apoptotic process [ISO]
- positive regulation of cytosolic calcium ion concentration [ISO]
- positive regulation of gastric acid secretion [ISO]
- positive regulation of nitric oxide biosynthetic process [ISO]
- response to heat [IMP, ISO]
- response to organonitrogen compound [IMP]
- response to pH [IMP, ISO]
- response to pain [IDA, IMP]
- sensory perception of mechanical stimulus [IMP]
- sensory perception of pain [IMP]
- signal transduction [ISO]
- smooth muscle contraction involved in micturition [IMP]
- temperature homeostasis [IMP]
- thermoception [ISO]
- urinary bladder smooth muscle contraction [IMP]
Gene Ontology Molecular Function- ATP binding [ISO]
- calcium channel activity [IMP]
- calcium-release channel activity [ISO]
- calmodulin binding [ISO]
- cation channel activity [ISA, ISO]
- cation transmembrane transporter activity [ISO]
- chloride channel regulator activity [ISO]
- excitatory extracellular ligand-gated ion channel activity [ISO]
- identical protein binding [ISO]
- ion channel activity [IDA]
- ligand-gated ion channel activity [ISO]
- phosphoprotein binding [ISO]
- transmembrane signaling receptor activity [ISO]
- ATP binding [ISO]
- calcium channel activity [IMP]
- calcium-release channel activity [ISO]
- calmodulin binding [ISO]
- cation channel activity [ISA, ISO]
- cation transmembrane transporter activity [ISO]
- chloride channel regulator activity [ISO]
- excitatory extracellular ligand-gated ion channel activity [ISO]
- identical protein binding [ISO]
- ion channel activity [IDA]
- ligand-gated ion channel activity [ISO]
- phosphoprotein binding [ISO]
- transmembrane signaling receptor activity [ISO]
Gene Ontology Cellular Component
AKAP5
Gene Ontology Biological Process
- cellular protein complex disassembly [ISO]
- negative regulation of adenylate cyclase activity [ISO]
- negative regulation of ion transport [ISO]
- negative regulation of potassium ion transport [ISO]
- positive regulation of NFAT protein import into nucleus [ISO]
- positive regulation of adenylate cyclase activity [ISO]
- positive regulation of cAMP biosynthetic process [ISO]
- positive regulation of calcium ion transport into cytosol [ISO]
- positive regulation of dendrite morphogenesis [ISO]
- positive regulation of protein kinase A signaling [ISO]
- positive regulation of protein phosphorylation [ISO]
Gene Ontology Molecular Function- G-protein coupled receptor binding [ISO]
- GABA receptor binding [ISO]
- actin binding [ISO]
- adenylate cyclase binding [ISO]
- cadherin binding [ISO]
- kinase binding [ISO]
- protein binding [IPI]
- protein complex binding [ISO]
- protein domain specific binding [ISO]
- protein kinase A regulatory subunit binding [ISO]
- protein kinase binding [ISO]
- protein phosphatase 2B binding [ISO]
- G-protein coupled receptor binding [ISO]
- GABA receptor binding [ISO]
- actin binding [ISO]
- adenylate cyclase binding [ISO]
- cadherin binding [ISO]
- kinase binding [ISO]
- protein binding [IPI]
- protein complex binding [ISO]
- protein domain specific binding [ISO]
- protein kinase A regulatory subunit binding [ISO]
- protein kinase binding [ISO]
- protein phosphatase 2B binding [ISO]
Gene Ontology Cellular Component
- asymmetric synapse [ISO]
- basolateral plasma membrane [ISO]
- cytoplasm [ISO]
- dendrite membrane [ISO]
- dendritic shaft [ISO]
- dendritic spine [ISO]
- dendritic spine membrane [ISO]
- filopodium membrane [ISO]
- neuronal cell body [ISO]
- perinuclear region of cytoplasm [ISO]
- plasma membrane [ISO]
- postsynaptic density [ISO]
- protein complex [ISO]
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Protein kinase A anchoring via AKAP150 is essential for TRPV1 modulation by forskolin and prostaglandin E2 in mouse sensory neurons.
Phosphorylation-dependent modulation of the vanilloid receptor TRPV1 is one of the key mechanisms mediating the hyperalgesic effects of inflammatory mediators, such as prostaglandin E(2) (PGE(2)). However, little is known about the molecular organization of the TRPV1 phosphorylation complex and specifically about scaffolding proteins that position the protein kinase A (PKA) holoenzyme proximal to TRPV1 for effective and selective regulation of ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID