BAIT

FAN1

SPBC146.06c, SPBC146.06c
Fanconi-associated nuclease Fan1
GO Process (1)
GO Function (1)
GO Component (1)

Gene Ontology Molecular Function

Gene Ontology Cellular Component

Schizosaccharomyces pombe (972h)
PREY

RAL2

SPBC21.05c
Ras1-Scd pathway protein Ral2
Schizosaccharomyces pombe (972h)

Synthetic Lethality

A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.

Publication

The conserved Fanconi anemia nuclease Fan1 and the SUMO E3 ligase Pli1 act in two novel Pso2-independent pathways of DNA interstrand crosslink repair in yeast.

Fontebasso Y, Etheridge TJ, Oliver AW, Murray JM, Carr AM

DNA interstrand cross-links (ICLs) represent a physical barrier to the progression of cellular machinery involved in DNA metabolism. Thus, this type of adduct represents a serious threat to genomic stability and as such, several DNA repair pathways have evolved in both higher and lower eukaryotes to identify this type of damage and restore the integrity of the genetic material. Human ... [more]

DNA Repair (Amst.) Dec. 01, 2013; 12(12);1011-23 [Pubmed: 24192486]

Throughput

  • High Throughput

Ontology Terms

  • phenotype: inviable (APO:0000112) [resistance to chemicals (APO:0000087)]

Additional Notes

  • sensitivity to cisplatin

Curated By

  • BioGRID