A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.

Publication

The conserved Fanconi anemia nuclease Fan1 and the SUMO E3 ligase Pli1 act in two novel Pso2-independent pathways of DNA interstrand crosslink repair in yeast.

Fontebasso Y, Etheridge TJ, Oliver AW, Murray JM, Carr AM

DNA interstrand cross-links (ICLs) represent a physical barrier to the progression of cellular machinery involved in DNA metabolism. Thus, this type of adduct represents a serious threat to genomic stability and as such, several DNA repair pathways have evolved in both higher and lower eukaryotes to identify this type of damage and restore the integrity of the genetic material. Human ... [more]

DNA Repair (Amst.) Dec. 01, 2013; 12(12);1011-23 [Pubmed: 24192486]

Throughput

High Throughput

Ontology Terms

phenotype: inviable (APO:0000112) [resistance to chemicals (APO:0000087)]

Additional Notes

sensitivity to cisplatin

Curated By

BioGRID

Interaction Summary

FAN1

Gene Ontology Biological Process

Gene Ontology Molecular Function

5'-3' exonuclease activity [ISO]

Gene Ontology Cellular Component

RAL2