BAIT
FAN1
SPBC146.06c, SPBC146.06c
Fanconi-associated nuclease Fan1
GO Process (1)
GO Function (1)
GO Component (1)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Schizosaccharomyces pombe (972h)
PREY
SPBC13E7.03C
RNA hairpin binding protein (predicted)
GO Process (1)
GO Function (1)
GO Component (1)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Schizosaccharomyces pombe (972h)
Synthetic Lethality
A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.
Publication
The conserved Fanconi anemia nuclease Fan1 and the SUMO E3 ligase Pli1 act in two novel Pso2-independent pathways of DNA interstrand crosslink repair in yeast.
DNA interstrand cross-links (ICLs) represent a physical barrier to the progression of cellular machinery involved in DNA metabolism. Thus, this type of adduct represents a serious threat to genomic stability and as such, several DNA repair pathways have evolved in both higher and lower eukaryotes to identify this type of damage and restore the integrity of the genetic material. Human ... [more]
DNA Repair (Amst.) Dec. 01, 2013; 12(12);1011-23 [Pubmed: 24192486]
Throughput
- High Throughput
Ontology Terms
- phenotype: inviable (APO:0000112) [resistance to chemicals (APO:0000087)]
Additional Notes
- sensitivity to cisplatin
Curated By
- BioGRID