ERBB3
Gene Ontology Biological Process
- Schwann cell differentiation [ISO]
- axonogenesis [IEP]
- cellular response to insulin stimulus [IEP]
- circadian rhythm [IEP]
- cranial nerve development [ISO]
- endocardial cushion development [ISO]
- epidermal growth factor receptor signaling pathway [IMP]
- extrinsic apoptotic signaling pathway in absence of ligand [ISO]
- mammary gland involution [IEP]
- negative regulation of cell adhesion [ISO]
- negative regulation of neuron apoptotic process [ISO]
- negative regulation of secretion [ISO]
- negative regulation of signal transduction [ISO]
- neuron apoptotic process [ISO]
- odontogenesis [IEP]
- peptidyl-tyrosine phosphorylation [TAS]
- peripheral nervous system development [ISO]
- phosphatidylinositol 3-kinase signaling [ISO]
- positive regulation of glucose import [IMP]
- positive regulation of protein tyrosine kinase activity [ISO]
- regulation of cell proliferation [ISO]
- response to drug [IEP]
- response to wounding [IEP]
- signal transduction [ISO]
- skeletal muscle tissue development [IEP]
- tongue development [IEP]
- transmembrane receptor protein tyrosine kinase signaling pathway [TAS]
Gene Ontology Molecular Function- growth factor binding [ISO]
- identical protein binding [ISO]
- neuregulin binding [IMP]
- neuregulin receptor activity [IMP]
- protein heterodimerization activity [ISO]
- protein tyrosine kinase activator activity [ISO]
- protein tyrosine kinase activity [ISO]
- transmembrane receptor protein tyrosine kinase activity [TAS]
- growth factor binding [ISO]
- identical protein binding [ISO]
- neuregulin binding [IMP]
- neuregulin receptor activity [IMP]
- protein heterodimerization activity [ISO]
- protein tyrosine kinase activator activity [ISO]
- protein tyrosine kinase activity [ISO]
- transmembrane receptor protein tyrosine kinase activity [TAS]
Gene Ontology Cellular Component
RPL13A
Gene Ontology Biological Process
- RNA metabolic process [TAS]
- SRP-dependent cotranslational protein targeting to membrane [TAS]
- cellular protein metabolic process [TAS]
- cellular response to interferon-gamma [IDA]
- gene expression [TAS]
- mRNA metabolic process [TAS]
- negative regulation of formation of translation preinitiation complex [IDA]
- negative regulation of translation [IDA, IMP]
- nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [TAS]
- translation [NAS, TAS]
- translational elongation [TAS]
- translational initiation [TAS]
- translational termination [TAS]
- viral life cycle [TAS]
- viral process [TAS]
- viral transcription [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Reconstituted Complex
An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator.
Publication
Interaction of the p23/p198 protein with ErbB-3.
The processes by which the kinase inactive receptor ErbB-3 transmits the signals of its ligand, heregulin (HRG), are incompletely understood. We used a yeast two-hybrid system to identify ErbB-3 interacting proteins that may participate in HRG signal transduction. We found that the protein p23, the human homolog of the mouse transplantation antigen P198, interacted with the cytoplasmic domain of ErbB-3 ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| ERBB3 RPL13A | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - | |
| ERBB3 RPL13A | Two-hybrid Two-hybrid Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation. | Low | - | BioGRID | - |
Curated By
- BioGRID