BAIT
MIB1
DIP-1, DIP1, LVNC7, MIB, ZZANK2, ZZZ6
mindbomb E3 ubiquitin protein ligase 1
GO Process (3)
GO Function (2)
GO Component (3)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Homo sapiens
PREY
RBBP4
NURF55, RBAP48, lin-53
retinoblastoma binding protein 4
GO Process (12)
GO Function (7)
GO Component (9)
Gene Ontology Biological Process
- ATP catabolic process [IDA]
- ATP-dependent chromatin remodeling [IDA]
- CENP-A containing nucleosome assembly [TAS]
- DNA replication-dependent nucleosome assembly [IDA]
- DNA replication-independent nucleosome assembly [IDA]
- G2/M transition of mitotic cell cycle [TAS]
- chromatin assembly [IDA]
- chromatin remodeling [IDA]
- mitotic cell cycle [TAS]
- negative regulation of cell proliferation [TAS]
- nucleosome assembly [TAS]
- regulation of cell cycle [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
TopBP1 Controls BLM Protein Level to Maintain Genome Stability.
Human TopBP1 is a key mediator protein involved in DNA replication checkpoint control. In this study, we report a specific interaction between TopBP1 and Bloom syndrome helicase (BLM) that is phosphorylation and cell-cycle dependent. Interestingly, TopBP1 depletion led to decreased BLM protein level and increased sister chromatid exchange (SCE). Moreover, our data indicated that BLM was ubiquitinated by E3 ligase ... [more]
Mol. Cell Nov. 12, 2013; 0(0); [Pubmed: 24239288]
Throughput
- Low Throughput
Curated By
- BioGRID