GABBR1
Gene Ontology Biological Process
- adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway [ISO, ISS]
- gamma-aminobutyric acid signaling pathway [ISO, ISS]
- negative regulation of adenylate cyclase activity [IDA, IMP]
- negative regulation of cell proliferation [IMP]
- negative regulation of dopamine secretion [IDA]
- negative regulation of epinephrine secretion [IMP]
- negative regulation of gamma-aminobutyric acid secretion [IMP]
- negative regulation of synaptic transmission [IDA]
- osteoblast differentiation [IMP]
- positive regulation of glutamate secretion [IMP]
- positive regulation of growth hormone secretion [IMP]
- regulation of cAMP biosynthetic process [IDA]
- regulation of glutamate secretion [IDA]
- response to ethanol [IEP]
- response to nicotine [IEP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- G-protein coupled receptor dimeric complex [ISO]
- G-protein coupled receptor heterodimeric complex [ISO, ISS]
- axolemma [IDA]
- cytoplasm [ISO]
- dendritic shaft [IDA]
- dendritic spine [IDA]
- endoplasmic reticulum membrane [IDA]
- extracellular space [IDA]
- integral component of plasma membrane [ISO, ISS]
- intracellular membrane-bounded organelle [IDA]
- membrane [ISO]
- membrane raft [IDA]
- mitochondrial membrane [IDA]
- neuron projection [IDA]
- neuronal cell body [IDA]
- postsynaptic membrane [ISO]
- presynaptic membrane [ISO]
- synaptic vesicle [IDA]
UBC
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Endoplasmic Reticulum-associated Degradation Controls Cell Surface Expression of γ-Aminobutyric Acid, Type B Receptors.
Metabotropic GABAB receptors are crucial for controlling the excitability of neurons by mediating slow inhibition in the CNS. The strength of receptor signaling depends on the number of cell surface receptors, which is thought to be regulated by trafficking and degradation mechanisms. Although the mechanisms of GABAB receptor trafficking are studied to some extent, it is currently unclear whether receptor ... [more]
Throughput
- Low Throughput
Additional Notes
- likely ubiquitin conjugate
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| UBC GABBR1 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | Low | - | BioGRID | - |
Curated By
- BioGRID