BAIT
HECW2
NEDL2
HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2
GO Process (1)
GO Function (1)
GO Component (2)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Homo sapiens
PREY
LACRT
lacritin
GO Process (10)
GO Function (6)
GO Component (3)
Gene Ontology Biological Process
- calcineurin-NFAT signaling cascade [IDA]
- calcium-mediated signaling [IDA]
- positive regulation of NFAT protein import into nucleus [IDA]
- positive regulation of cell proliferation [IDA]
- positive regulation of epithelial cell proliferation [IDA]
- positive regulation of peptidyl-tyrosine phosphorylation [IDA]
- positive regulation of release of sequestered calcium ion into cytosol [IDA]
- positive regulation of secretion [IDA]
- protein localization to Golgi apparatus [IDA]
- tear secretion [NAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
HECT Type Ubiquitin Ligase NEDL2 is Degraded by APC/C-Cdh1 and its Tight Regulation Maintains the Metaphase to Anaphase Transition.
NEDD4-like ubiquitin ligase 2 (NEDL2) is a HECT type ubiquitin ligase. NEDL2 enhances p73 transcriptional activity and degrades ATR kinase in lamin misexpressed cells. Compared to the important functions of other HECT type ubiquitin ligase, there is less study concerning the function and regulation of NEDL2. Using primary antibody immunoprecipitation and mass spectrometry (IP/MS), we identify a list of potential ... [more]
J. Biol. Chem. Oct. 25, 2013; 0(0); [Pubmed: 24163370]
Throughput
- High Throughput
Curated By
- BioGRID